Abstract
A model of cardiac microstructure and diffusion MRI is presented. The results show a good correspondence between the simulated and experimental measurements. A sensitivity analysis shows that the diffusivity has the greatest effect on both the apparent diffusion coefficient and the fractional anisotropy. The cross-sectional area of the cells is the next most important factor; the aspect ratio of the cell cross-section also affects the fractional anisotropy. Neither the cell length nor the volume fraction of cells has a marked effect.
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Acknowledgements
This work is supported by a BBSRC grant (BB/I012117/1), an EPSRC grant (EP/J013250/1) and by funding from the British Heart Foundation (BHF) Centre for Research Excellence. JES and PK are BHF Senior Basic Science Research Fellows (FS/11/50/29038; FS/12/17/29532). VG and PK are supported by BHF New Horizon Grant NH/13/30238. PK holds an ERC Advanced Grant (CardioNect). The authors acknowledge a Wellcome Trust Core Award (090532/Z/09/Z).
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Bates, J., Teh, I., Kohl, P., Schneider, J.E., Grau, V. (2015). Sensitivity Analysis of Diffusion Tensor MRI in Simulated Rat Myocardium. In: van Assen, H., Bovendeerd, P., Delhaas, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2015. Lecture Notes in Computer Science(), vol 9126. Springer, Cham. https://doi.org/10.1007/978-3-319-20309-6_14
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DOI: https://doi.org/10.1007/978-3-319-20309-6_14
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