Abstract
The MinCDE protein system exists in Escherichia coli and some other bacteria. It prevents the bacteria from incorrect cell division. Recent studies of MinCDE behavior in vitro showed it exhibits selforganization forming protein autowaves and some other patterns. There is a proposition that autowaves arises from an interplay of two opposing mechanisms: cooperative binding of MinD to the membrane, and accelerated MinD detachment due to persistent MinE rebinding. On the basis of this proposition we have developed a cellular automaton model of the process. The behavior of protein concentration, obtained as a result of computer simulations, reveals similarity with the results of experiments in vitro. In addition, the protein autowaves resulting from computational experiments are similar to those that emerge in vitro.
Supported by RFBR under Grant 14-01-31425- mol-a.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lutkenhaus, J.: Assembly dynamics of the bacterial MinCDE system and spatial regulation ofthe Z ring. Annu. Rev. Biochem. 76, 539–562 (2007)
Loose, M., Fischer-Friedrich, E., Herold, C., Kruse, K., Schwille, P.: Min protein patterns emerge from rapid rebinding and membrane interaction of MinE. Nat. Struct. Mol. Biol. 18(5), 577–583 (2011). doi:10.1038/nsmb.2037
Ivanov, V., Mizuuchi, K.: Multiple modes of interconverting dynamic pattern formation by bacterial cell division proteins. Proc. Natl. Acad. Sci. 107(18), 8071–8078 (2010)
Bandman, O.: Cellular automata composition techniques for spatial dynamics simulation. In: Hoekstra, A.G., et al. (eds.) Simulating Complex Systems by Cellular Automata: Understanding Complex Systems, pp. 81–115. Springer, Heidelberg (2010)
Toffolli, T., Margolus, N.: Cellular Automata Machines: A New Environment for Modeling. MIT Press, Cambridge (1987)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Vitvitsky, A. (2015). CA - Model of Autowaves Formation in the Bacterial MinCDE System. In: Malyshkin, V. (eds) Parallel Computing Technologies. PaCT 2015. Lecture Notes in Computer Science(), vol 9251. Springer, Cham. https://doi.org/10.1007/978-3-319-21909-7_23
Download citation
DOI: https://doi.org/10.1007/978-3-319-21909-7_23
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-21908-0
Online ISBN: 978-3-319-21909-7
eBook Packages: Computer ScienceComputer Science (R0)