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Challenges in Synthesizing Surrogate PHI in Narrative EMRs

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Medical Data Privacy Handbook

Abstract

Preparing narrative medical records for use outside of their originating institutions requires that protected health information (PHI) be removed from the records. If researchers intend to use these records for natural language processing, then preparing the medical documents requires two steps: (1) identifying the PHI and (2) replacing the PHI with realistic surrogates. In this chapter we discuss the challenges associated with generating these realistic surrogates and describe the algorithms we used to prepare the 2014 i2b2/UTHealth shared task corpus for distribution and use in a natural language processing task focused on de-identification.

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Notes

  1. 1.

    Somewhat confusingly, “re-identification” is also sometimes used to refer to determining a person’s true identity from de-identified data [7], so we avoid that term for the remainder of this chapter.

  2. 2.

    Informatics for Integrating Biology and the Bedside.

  3. 3.

    University of Texas Health Science Center at Houston.

  4. 4.

    45 CFR 164.514.

  5. 5.

    http://www.asbestos.com/occupations/.

References

  1. Berman, J.J.: Concept-match medical data scrubbing. How pathology text can be used in research. Arch. Pathol. Lab. Med. 127(6), 680–6 (2003)

    Google Scholar 

  2. Chakaravarthy, V.T., Gupta, H., Roy, P., Mohania, M.K.: Efficient techniques for document sanitization. In: Proceedings of the 17th ACM conference on Information and knowledge management, pp. 843–852 (2008)

    Google Scholar 

  3. Clifford, G.D., Scott, D.J., Villarroel, M.: User Guide and Documentation for the MIMIC II Database, database version 2.6. Available online: https://mimic.physionet.org/UserGuide/UserGuide.html (2012)

  4. Deleger, L., Lingren, T., Ni, Y., Kaiser, M., Stoutenborough, L., Marsolo, K., Kouril, M., Molnar, K., Solti, I.: Preparing an annotated gold standard corpus to share with extramural investigators for de-identification research. J. Biomed. Inform. Aug;50:173–83 (2014). doi: 10.1016/j.jbi.2014.01.014

    Google Scholar 

  5. Douglass M.M.: Computer-assisted de-identification of free-text nursing notes. MEng thesis, Massachusetts Institute of Technology (2005)

    Google Scholar 

  6. Douglass M.M, Clifford, G.D., Reisner, A., Moody, G.B., Mark, R.G.: Computer-assisted deidentification of free text in the MIMIC II database. Comput. Cardiol. 31, 341–344 (2004)

    Google Scholar 

  7. El Emam, K., Buckeridge, D., Tamblyn, R., Neisa, A., Jonker, E., Verma, A.: The re-identification risk of Canadians from longitudinal demographics. BMC Med. Inform. Decis. Mak. 11, 46 (2011)

    Article  Google Scholar 

  8. Gardner, J., Xiong, L.: An integrated framework for de-identifying unstructured medical data. Data Knowl. Eng. 68(12), 1441–1451 (2009)

    Article  Google Scholar 

  9. Goldberger, A.L., Amaral, L.A.N., Glass, L., Hausdorff, J.M., Ivanov, P., Mark, R.G., Mietus, J.E., Moody, G.B., Peng, C.-K., Stanley, H.E.: PhysioBank, PhysioToolkit, and Physionet: components of a new research resource for complex physiologic signals. Circulation 101(23), e215-e220 (June 13, 2000). http://circ.ahajournals.org/cgi/content/full/101/23/e215

  10. Golle, P.: Revisiting the uniqueness of simple demographics in the US population. In: Workshop on Privacy in the Electronic Society (2006)

    Book  Google Scholar 

  11. Gupta, D., Saul, M., Gilbertson, J.: Evaluation of a deidentification (De-Id) software engine to share pathology reports and clinical documents for research. Am. J. Clin. Pathol. 121(2), 176–186 (2004)

    Article  Google Scholar 

  12. HHS (Department of Health and Human Services). Standards for Privacy of Individually Identifiable Health Information, 45 CFR Parts 160 and 164. December 3, 2002 Revised April 3, 2003. Available from: http://www.hhs.gov/ocr/privacy/hipaa/understanding/coveredentities/introdution.html

  13. Jiang, W., Murugesan, M., Clifton, C., Si, L.: t-Plausibility: semantic preserving text sanitization. In: 2009 International Conference on Computational Science and Engineering (CSE), pp. 68–75 (2009). doi:10.1109/CSE.2009.353

    Google Scholar 

  14. Kumar, V., Stubbs, A., Shaw, S., Uzuner, O.: Creation of a new longitudinal corpus of clinical narratives. J. Biomed. Inform. 2015.

    Google Scholar 

  15. Kushida, C.A., Nichols, D.A., Jadrnicek, R., Miller, R., Walsh, J.K., Griffin, K.: Strategies for de-identification and anonymization of electronic health record data for use in multicenter research studies. Med. Care 50, S82–S101 (2012)

    Article  Google Scholar 

  16. Lafferty, J., McCallum, A., Pereira, F.: Conditional random fields: probabilistic models for segmenting and labeling sequence data. In: Proceedings of the 18th International Conference on Machine Learning, pp. 282–289. Morgan Kaufmann, San Francisco (2001)

    Google Scholar 

  17. Lafky, D.: The Safe Harbor method of de-identification: an empirical test. Fourth National HIPAA Summit West. http://www.ehcca.com/presentations/HIPAAWest4/lafky_2.pdf (2010)

  18. Levenshtein, V.I.: Binary codes capable of correcting deletions, insertions, and reversals. Doklady Akademii Nauk SSSR. 163(4), 845–848 (1965) [Russian]. English translation in Sov. Phys. Dokl. 10(8), 707–710 (1966)

    Google Scholar 

  19. Li, M., Carrell, D., Aberdeen, J., Hirschman, L., Malin, B.: De-identification of clinical narratives through writing complexity measures. Int. J. Med. Inform. 83(10), 750–767 (2014)

    Article  Google Scholar 

  20. McMurry, A.J., Fitch, B., Savova, G., Kohane, I.S., Reis, B.Y.: Improved de-identification of physician notes through integrative modeling of both public and private medical text. BMC Med. Inform. Decis. Mak. 13, 112 (2013). doi:10.1186/1472-6947-13-112

    Article  Google Scholar 

  21. Meystre, S., Friedlin, F., South, B., Shen, S., Samore, M.: Automatic de-identification of textual documents in the electronic health record: a review of recent research. BMC Med. Res. Methodol. 10, 70 (2010)

    Article  Google Scholar 

  22. Meystre, S., Shen, S., Hofmann, D., Gundlapalli, A.: Can physicians recognize their own patients in de-identified notes? Stud. Health Technol. Inform. Stud Health Technol Inform. 2014;205:778–82

    Google Scholar 

  23. Neamatullah, I., Douglass, M., Lehman, L.-W., Reisner, A., Villarroel, M., Long, W., Szolovits, P., Moody, G., Mark, R., Clifford, G.: Automated de-identification of free-text medical records. BMC Med. Inform. Decis. Mak. 8, 32 (2008)

    Article  Google Scholar 

  24. Stubbs, A., Kotfila, C., Uzuner, Ö.: Automated systems for the de-identification of longitudinal clinical narratives. J Biomed Inform. 2015 Jul 28. pii: S1532-0464(15)00117-3. doi: 10.1016/j.jbi.2015.06.007

    Google Scholar 

  25. Stubbs, A., Uzuner, Ö.: Annotating longitudinal clinical narratives for de-identification: The 2014 i2b2/UTHealth corpus J Biomed Inform. 2015 Aug 28. pii: S1532-0464(15)00182-3. doi: 10.1016/j.jbi.2015.07.020

    Google Scholar 

  26. Sun, W., Rumshishky, A., Uzuner, Ö.: Evaluating temporal relations in clinical text: 2012 i2b2 Challenge. J. Am. Med. Inform. Assoc. Published Online First 5 April 2013

    Google Scholar 

  27. Sweeney, L.: Replacing personally-identifying information in medical records, the scrub system. In: Cimino, J.J. (ed.) Proceedings, Journal of the American Medical Informatics Association, pp. 333–337. Hanley and Belfus, Washington (1996)

    Google Scholar 

  28. Sweeney, L.: Uniqueness of Simple Demographics in the U.S. Population. Carnegie Mellon University, School of Computer Science, Data Privacy Laboratory, Technical Report LIDAP-WP4. Pittsburgh (2000)

    Google Scholar 

  29. Uzuner, Ö., Luo, Y., Szolovits, P.: Evaluating the state-of-the-art in automatic de-identification. J. Am. Med. Inform. Assoc. 14(5), 550–563 (2007)

    Article  Google Scholar 

  30. Uzuner, Ö., Stubbs, A., Xu, H., co-chairs.: “Data Release and Call for Participation: 2014 i2b2/UTHealth Shared-Tasks and Workshop on Challenges in Natural Language Processing for Clinical Data”. https://www.i2b2.org/NLP/HeartDisease/

  31. Yeniterzi, R., Aberdeen, J., Bayer, S., Wellner, B., Hirschman, L., Malin, B.: Effects of personal identifier resynthesis on clinical text de-identification. J. Am. Med. Inform. Assoc. 17, 159–168 (2010)

    Article  Google Scholar 

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Acknowledgements

This project was funded by NIH NLM 2U54LM008748 PI: Isaac Kohane, and by NIH NLM 5R13LM011411 PI: Ozlem Uzuner.

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Correspondence to Amber Stubbs .

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Stubbs, A., Uzuner, Ö., Kotfila, C., Goldstein, I., Szolovits, P. (2015). Challenges in Synthesizing Surrogate PHI in Narrative EMRs. In: Gkoulalas-Divanis, A., Loukides, G. (eds) Medical Data Privacy Handbook. Springer, Cham. https://doi.org/10.1007/978-3-319-23633-9_27

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  • DOI: https://doi.org/10.1007/978-3-319-23633-9_27

  • Publisher Name: Springer, Cham

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