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Simple Fabrication Method of Micro-Fluidic Devices with Thick Resist Flow Paths Designed Arbitrarily Using Versatile Computer Aided Design Tools

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Biomedical Engineering Systems and Technologies (BIOSTEC 2014)

Abstract

A simple and easy fabrication method of micro-fluidic devices using only single lithography processes was proposed. Thick resist patterns printed using a simple and handmade contact-lithography tool were directly used as flow-path patterns. Because pattern widths were as large as 50–200 μm, low-cost film reticles were applicable. Accordingly, various flow-path shapes were designed arbitrarily using a versatile computer aided design tool, and easily obtained in very quick turn-around times at very low costs. The sidewalls of flow paths were controlled almost vertical using long-wavelength exposure light. The flow paths formed on a silicon wafer chip were easily capped by sandwiching them between a vessel and lid plates using bolts and nuts. Even when two colored waters were simultaneously injected from the two inlet ports of a swirl-type micro-mixer, they did not leak at all in spite of such simple assemblies. The new fabrication method of micro-fluidic devices using thick resist patterning will be useful for various applications.

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References

  1. Bouhadda, I., Sagazan, O., Bihan, F.L.: Suspended gate field effect transistor with an integrated micro-fluidic channel performed by surface micromachining for liquids sensing. Procedia Eng. 47, 754–757 (2012)

    Article  Google Scholar 

  2. Curto, V.F., Fay, C., Coyle, S., Byrne, R., O’Toole, C., Barry, C., Hughes, S., Moyna, N., Diamond, D., Lopez, F.B.: Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids. Sens. Actuators B 171–172, 1327–1334 (2012)

    Article  Google Scholar 

  3. Kashkary, L., Kemp, C., Shaw, K.J., Greenway, G.M., Haswell, S.J.: Improved DNA extraction efficiency from low level cell numbers using a silica monolith based micro fluidic device. Anal. Chim. Acta 750, 127–131 (2012)

    Article  Google Scholar 

  4. Jacobs, T., Kutzner, C., Kropp, M., Brokmann, G., Lang, W., Steinke, A., Kienke, A., Hauptmann, P.: Combination of a novel perforated thermoelectric flow and impedimetric sensor for monitoring chemical conversion in micro fluidic channels. Procedia Chem. 1, 1127–1130 (2009)

    Article  Google Scholar 

  5. Avram, M., Iliescu, C., Volmer, M., Avram, A.: Microfluidic device for magnetic separation in lab-on-a-chip systems. In: 21st International Microprocesses and Nanotechnology Conference Digest of Papers, Microprocesses and Nanotechnology pp. 442–443 (2008)

    Google Scholar 

  6. Eun, D.S., Kong, D.Y., Chang, S.J., Yoo, J.H., Hong, Y.M., Shin, J.K., Lee, J.H.: Micro-PCR Chip with Nanofluidic Heat-Sink for Faster Temperature Changes. In: 21st International Microprocesses and Nanotechnology Conference Digest of Papers, Microprocesses and Nanotechnology 2008, pp. 448–449 (2008)

    Google Scholar 

  7. Lopez, F.B., Scarmagnani, S., Walsh, Z., Paull, B., Macka, M., Diamond, D.: Spiropyran modified micro-fluidic chip channel as photonically controlled self-indicating system for metal ion accumulation and release. Sens. Actuators B 140, 295–303 (2009)

    Article  Google Scholar 

  8. Campbel, K., McGrath, T., Sjölander, S., Hanson, T., Tidare, M., Jansson, Ö., Moberg, A., Mooney, M., Elliott, C., Buijs, J.: Use of a novel micro-fluidic device to create arrays for multiplex analysis of large and small molecular weight compounds by surface plasmon resonance. Biosens. Bioelectron. 26, 3029–3036 (2011)

    Article  Google Scholar 

  9. Chen, C.S., Chen, S.C., Liao, W.H., Chien, R.D., Lin, S.H.: Micro injection molding of a micro-fluidic platform. Int. Commun. Heart Mass Transf. 37, 1290–1294 (2010)

    Article  Google Scholar 

  10. Oakley, J.A., Robinson, S., Dyer, C.E., Greenman, J., Greenway, G.M., Haswell, S.J.: Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Anal. Chim. Acta 652, 239–244 (2009)

    Article  Google Scholar 

  11. Yang, R., Lu, B.R., Wang, J., Xie, S.Q., Chen, Y., Huq, E., Qu, X.P., Liu, R.: Fabrication of micro/nano fluidic channels by nanoimprint lithography and bonding using SU-8. Microelectron. Eng. 86, 1379–1381 (2009)

    Article  Google Scholar 

  12. Horiuchi, T., Watanabe, H., Hayashi, N., Kitamura, T.: Simply fabricated precise microfluidic mixer with resist flow paths sealed by an acrylic lid. In: Proceedings of The third International Conference on Biomedical Electronics and Devices, pp. 82-87 (2010)

    Google Scholar 

  13. Horiuchi, T., Yoshino, S.: Fabrication of precise micro-fluidic devices using a low-cost and simple contact-exposure tool for lithography, In: Proceedings of The 7th International Conference on Biomedical Electronics and Devices, pp. 5–11 (2014)

    Google Scholar 

  14. Martinez, A.W., Phillips, S.T., Wiley, B.J., Gupta, M., Whiteside, G.M.: FLASH: a rapid method for prototyping paper-based microfluidic devices. Lab Chip 8(12), 2146–2150 (2008)

    Article  Google Scholar 

  15. Martinez, A.W., Phillips, S.T., Whiteside, G.M., Carrilho, E.: Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal. Chem. 82, 3–10 (2010)

    Article  Google Scholar 

  16. Horiuchi, T., Shinoda, D.: Feasibility of a micro-fluidic health care device measuring content of sodium chloride. In: Proceedings of The 5th International Conference on Biomedical Electronics and Devices, pp. 297–301 (2012)

    Google Scholar 

  17. Jain, M., Nandakumar, K.: Optimal patterning of heterogeneous surface charge for improved electrokinetic micromixing. Comput. Chem. Eng. 49, 18–24 (2013)

    Article  Google Scholar 

  18. Rahimi, M., Azimi, N., Parvian, F., Alsairafi, A.A.: Computational Fluid Dynamics modelling of micromixing performance in presence of microparticles in a tubular sonoreactor. Computer and Chemical Engineering 60, 403–412 (2014)

    Article  Google Scholar 

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Acknowledgements

This work was partially supported by Research Institute for Science and Technology of Tokyo Denki University, Grant Number Q13T-02.

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Correspondence to Toshiyuki Horiuchi .

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Horiuchi, T., Yoshino, S., Miyanishi, J. (2015). Simple Fabrication Method of Micro-Fluidic Devices with Thick Resist Flow Paths Designed Arbitrarily Using Versatile Computer Aided Design Tools. In: Plantier, G., Schultz, T., Fred, A., Gamboa, H. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2014. Communications in Computer and Information Science, vol 511. Springer, Cham. https://doi.org/10.1007/978-3-319-26129-4_2

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  • DOI: https://doi.org/10.1007/978-3-319-26129-4_2

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