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Construction of Protein Phosphorylation Network Based on Boolean Network Methods Using Proteomics Data

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Intelligent Computing Theories and Application (ICIC 2016)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 9771))

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Abstract

Post-translational Modification (PTM) of Proteins is a key biological process in the regulation of protein function. This paper discusses the problem of construction of PTM network based on the reverse engineering principles, which is constructed by using PBIL and TDE algorithms. Experiments which are based on two well-known pathways by the time series data of protein phosphorylation data show that the new method can be successfully validated and further reveal the regulation of protein phosphorylation.

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Acknowledgement

This research was partially supported by Program for Scientific research innovation team in Colleges and universities of Shandong Province 2012–2015, the Key Project of Natural Science Foundation of Shandong Province (ZR2011FZ001), the Natural Science Foundation of Shandong Province (ZR2011FL022, ZR2013FL002), the Youth Science and Technology Star Program of Jinan City (201406003), the Shandong Provincial Key Laboratory of Network Based Intelligent Computing and Shandong Provincial Natural Science Foundation, China, under Grant ZR2015JL025. This work was also supported by the National Natural Science Foundation of China (Grant No. 61302128) and Shandong Distinguished Middle-Aged and Young Scientist Encourage and Reward Foundation Grant BS2014DX015. Research Fund for the Doctoral Program of University of Jinan (No. XBS1604). The scientific research foundation of University of Jinan (XKY1410, XKY1411). Authors would like to thank Huixiang Xu of School of Information Science and Engineering, University of Jinan. Thanks the anonymous referees for the technical suggestions and remarks which helped to improve the contents and the quality of presentation.

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Authors and Affiliations

  1. School of Information Science and Engineering, University of Jinan, Jinan, 250022, China

    Han Yu, Yaou Zhao, Shiyuan Han, Yuehui Chen & Likai Dong

  2. Shandong Provincial Key Laboratory of Network Based Intelligent Computing, Jinan, 250022, China

    Han Yu, Yaou Zhao, Shiyuan Han & Yuehui Chen

  3. School of Biological Science and Technology, University of Jinan, Jinan, 250022, China

    Wenxing He

Authors
  1. Han Yu
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  2. Yaou Zhao
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  3. Shiyuan Han
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  4. Yuehui Chen
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  5. Wenxing He
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  6. Likai Dong
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Corresponding authors

Correspondence to Yuehui Chen or Wenxing He .

Editor information

Editors and Affiliations

  1. Tongji University , Shanghai, China

    De-Shuang Huang

  2. Polytechnic of Bari , Bari, Italy

    Vitoantonio Bevilacqua

  3. University of Wollongong , North Wollongong, New South Wales, Australia

    Prashan Premaratne

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© 2016 Springer International Publishing Switzerland

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Yu, H., Zhao, Y., Han, S., Chen, Y., He, W., Dong, L. (2016). Construction of Protein Phosphorylation Network Based on Boolean Network Methods Using Proteomics Data. In: Huang, DS., Bevilacqua, V., Premaratne, P. (eds) Intelligent Computing Theories and Application. ICIC 2016. Lecture Notes in Computer Science(), vol 9771. Springer, Cham. https://doi.org/10.1007/978-3-319-42291-6_26

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  • DOI: https://doi.org/10.1007/978-3-319-42291-6_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42290-9

  • Online ISBN: 978-3-319-42291-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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