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Big Biological Data Management

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Resource Management for Big Data Platforms

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Abstract

With the deluge of omics data, the life sciences have become a big data science. The management and analysis of omics data share many of the challenges and technical solutions of other big data fields. However, there are also unique challenges. In particular, there is a need for data management solutions that are backward compatible with unmodified tools, but at the same timescales to large-scale datasets, and in addition manages the intermediate, metadata, and provenance data of analysis pipelines. In this chapter, we present and discuss challenges and approaches for such big biological data management.

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References

  1. Abadi, D., Agrawal, R., Ailamaki, A., Balazinska, M., Bernstein, P.A., Carey, M.J., Chaudhuri, S., Chaudhuri, S., Dean, J., Doan, A., Franklin, M.J., Gehrke, J., Haas, L.M., Halevy, A.Y., Hellerstein, J.M., Ioannidis, Y.E., Jagadish, H.V., Kossmann, D., Madden, S., Mehrotra, S., Milo, T., Naughton, J.F., Ramakrishnan, R., Markl, V., Olston, C., Ooi, B.C., Ré, C., Suciu, D., Stonebraker, M., Walter, T., Widom, J.: The beckman report on database research. Commun. ACM 59(2), 92–99 (2016)

    Article  Google Scholar 

  2. Abu-Doleh, A., Atalyrek, V.: Spaler: Spark and graphx based de novo genome assembler. In: 2015 IEEE International Conference on Big Data (Big Data), pp. 1013–1018 (2015)

    Google Scholar 

  3. Apache: Apache HBase. http://hbase.apache.org. Cited 18 April 2016

  4. Apache: Avro. http://avro.apache.org. Cited 18 April 2016

  5. Apache: Cassandra. http://cassandra.apache.org. Cited 18-April-2016

  6. Bhatotia, P., Wieder, A., Rodrigues, R., Acar, U.A., Pasquini, R.: Incoop: MapReduce for Incremental Computations. In: Proceedings of the 2nd ACM Symposium on Cloud Computing, p. 7. ACM Press (2011)

    Google Scholar 

  7. Bongo, L.A., Pedersen, E., Ernstsen, M.: Data-intensive computing infrastructure systems for unmodified biological data analysis pipelines. In: Computational Intelligence Methods for Bioinformatics and Biostatistics, LNBI, vol. 8623 (2014)

    Google Scholar 

  8. Dean, J., Ghemawat, S.: MapReduce. Commun. ACM 51(1), 107 (2008)

    Article  Google Scholar 

  9. Diao, Y., Roy, A., Bloom, T.: Building highly-optimized, low-latency pipelines for genomic data analysis. In: Proceedings of 7th Biennial Conference on Innovative Data Systems Research (2015)

    Google Scholar 

  10. Edgar, R., Domrachev, M., Lash, A.E.: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30(1), 207–210 (2002)

    Article  Google Scholar 

  11. EMBL-European Bioinformatics Institute: EMBL-EBI Annual Scientific Report 2014. http://www.ebi.ac.uk/about/brochures. Cited 18 April 2016

  12. Fernández-Suárez, X.M., Rigden, D.J., Galperin, M.Y.: The 2014 nucleic acids research database issue and an updated NAR online molecular biology database collection. Nucleic Acids Res. 42(Database issue), D1–6 (2014)

    Google Scholar 

  13. Fitzpatrick, B.: Distributed caching with memcached. Linux J. 2004(124), 5 (2004)

    Google Scholar 

  14. Gentleman, R.C., Carey, V.J., Bates, D.M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., Hornik, K., Hothorn, T., Huber, W., Iacus, S., Irizarry, R., Leisch, F., Li, C., Maechler, M., Rossini, A.J., Sawitzki, G., Smith, C., Smyth, G., Tierney, L., Yang, J.Y.H., Zhang, J.: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5(10), R80 (2004)

    Article  Google Scholar 

  15. Ghemawat, S., Gobioff, H., Leung, S.T.: The google file system. In: Proceedings of the Nineteenth ACM Symposium on Operating Systems Principles. SOSP ’03, pp. 29–43. ACM, New York, NY, USA (2003)

    Google Scholar 

  16. Goecks, J., Nekrutenko, A., Taylor, J.: Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol. 11(8), R86 (2010)

    Article  Google Scholar 

  17. Gonzalez, J.E., Xin, R.S., Dave, A., Crankshaw, D., Franklin, M.J., Stoica, I.: Graphx: Graph processing in a distributed dataflow framework. In: 11th USENIX Symposium on Operating Systems Design and Implementation (OSDI 14), pp. 599–613. USENIX Association, Broomfield, CO (2014)

    Google Scholar 

  18. Gupta, A., Agarwal, D., Tan, D., Kulesza, J., Pathak, R., Stefani, S., Srinivasan, V.: Amazon redshift and the case for simpler data warehouses. In: Proceedings of the 2015 ACM SIGMOD International Conference on Management of Data. SIGMOD ’15, pp. 1917–1923. ACM, New York, NY, USA (2015)

    Google Scholar 

  19. Have, C.T., Jensen, L.J.: Are graph databases ready for bioinformatics? Bioinformatics 29(24), 3107–3108 (2013)

    Article  Google Scholar 

  20. Kornacker, M., Behm, A., Bittorf, V., Bobrovytsky, T., Ching, C., Choi, A., Erickson, J., Grund, M., Hecht, D., Jacobs, M., Joshi, I., Kuff, L., Kumar, D., Leblang, A., Li, N., Pandis, I., Robinson, H., Rorke, D., Rus, S., Russell, J., Tsirogiannis, D., Wanderman-Milne, S., Yoder, M.: Impala: A modern, open-source sql engine for hadoop. In: CIDR. www.cidrdb.org (2015)

  21. Kovatch, P., Costa, A., Giles, Z., Fluder, E., Cho, H.M., Mazurkova, S.: Big omics data experience. In: Proceedings of the International Conference for High Performance Computing, Networking, Storage and Analysis, SC ’15, pp. 39:1–39:12. ACM, New York, NY, USA (2015)

    Google Scholar 

  22. Leinonen, R., Akhtar, R., Birney, E., Bower, L., Cerdeno-Tárraga, A., Cheng, Y., Cleland, I., Faruque, N., Goodgame, N., Gibson, R., Hoad, G., Jang, M., Pakseresht, N., Plaister, S., Radhakrishnan, R., Reddy, K., Sobhany, S., Hoopen, P.T., Vaughan, R., Zalunin, V., Cochrane, G.: The European nucleotide archive. Nucleic Acids Res. 39(SUPPL. 1) (2011)

    Google Scholar 

  23. Leipzig, J.: A review of bioinformatic pipeline frameworks. Briefings in Bioinformatics (2016)

    Google Scholar 

  24. Malewicz, G., Austern, M.H., Bik, A.J., Dehnert, J.C., Horn, I., Leiser, N., Czajkowski, G.: Pregel: A system for large-scale graph processing. In: Proceedings of the 2010 ACM SIGMOD International Conference on Management of Data. SIGMOD ’10, pp. 135–146. ACM, New York, NY, USA (2010)

    Google Scholar 

  25. Melnik, S., Gubarev, A., Long, J.J., Romer, G., Shivakumar, S., Tolton, M., Vassilakis, T.: Dremel: interactive analysis of web-scale datasets. Proc. VLDB Endowment 3(1–2), 330–339 (2010)

    Article  Google Scholar 

  26. Nothaft, F.A., Massie, M., Danford, T., Zhang, Z., Laserson, U., Yeksigian, C., Kottalam, J., Ahuja, A., Hammerbacher, J., Linderman, M., Franklin, M.J., Joseph, A.D., Patterson, D.A.: Rethinking data-intensive science using scalable analytics systems. In: Proceedings of the 2015 ACM SIGMOD International Conference on Management of Data. SIGMOD ’15, pp. 631–646. ACM, New York, NY, USA (2015)

    Google Scholar 

  27. Olston, C., Chopra, S., Srivastava, U.: Generating example data for dataflow programs. In: Proceedings of the 2009 ACM SIGMOD International Conference on Management of Data. SIGMOD ’09, pp. 245–256. ACM, New York, NY, USA (2009)

    Google Scholar 

  28. Oracle: MySQL. http://www.mysql.com. Cited 18 April 2016

  29. Pedersen, E., Bongo, L.A.: Large-scale biological meta-database management. In: Future Generation Computer Systems (2016)

    Google Scholar 

  30. Pedersen, E., Raknes, I.A., Ernstsen, M., Bongo, L.A.: Integrating data-intensive computing systems with biological data analysis frameworks. In: Proceedings of 23rd Euromicro International Conference on Parallel, Distributed and Network-based Processing, pp. 733–740. IEEE (2015)

    Google Scholar 

  31. Robertsen, E.M., Kahlke, T., Raknes, I.A., Pedersen, E., Semb, E.K., Ernstsen, M., Bongo, L.A., Willassen, N.P.: Meta-pipe - pipeline annotation, analysis and visualization of marine metagenomic sequence data. arXiv:1604.04103 (2016)

  32. Schildgen, J., Jorg, T., Hoffmann, M., Dessloch, S.: Marimba: A framework for making mapreduce jobs incremental. In: 2014 IEEE International Congress on Big Data, pp. 128–135. IEEE (2014)

    Google Scholar 

  33. Schmuck, F., Haskin, R.: Gpfs: A shared-disk file system for large computing clusters. In: Proceedings of the 1st USENIX Conference on File and Storage Technologies, FAST ’02. USENIX Association, Berkeley, CA, USA (2002)

    Google Scholar 

  34. Shvachko, K., Kuang, H., Radia, S., Chansler, R.: The hadoop distributed file system. In: 2010 IEEE 26th Symposium on Mass Storage Systems and Technologies 0(5), 1–10 (2010)

    Google Scholar 

  35. Stajich, J.E., Block, D., Boulez, K., Brenner, S.E., Chervitz, S.A., Dagdigian, C., Fuellen, G., Gilbert, J.G.R., Korf, I., Lapp, H., Lehväslaiho, H., Matsalla, C., Mungall, C.J., Osborne, B.I., Pocock, M.R., Schattner, P., Senger, M., Stein, L.D., Stupka, E., Wilkinson, M.D., Birney, E.: The Bioperl toolkit: Perl modules for the life sciences. Genome Res. 12(10), 1611–1618 (2002)

    Article  Google Scholar 

  36. Twitter, and Cloudera: Parquet. http://www.parquet.io. Cited 18 April 2016

  37. UniProt Consortium: UniProt release 201504. http://www.uniprot.org/help/2015/04/01/release. Cited 18-April-2016

  38. Wang, D.L., Monkewitz, S.M., Lim, K.T., Becla, J.: Qserv: A distributed shared-nothing database for the lsst catalog. In: State of the Practice Reports, SC ’11, pp. 12:1–12:11. ACM, New York, NY, USA (2011)

    Google Scholar 

  39. Wetterstrand, K.: DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP). http://www.genome.gov/sequencingcosts. Cited 18-April-2016

  40. Zaharia, M., Chowdhury, M., Franklin, M.J., Shenker, S., Stoica, I.: Spark: Cluster Computing with Working Sets. In: Proceedings of the 2nd USENIX conference on Hot topics in cloud computing, p. 10 (2010)

    Google Scholar 

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Correspondence to Edvard Pedersen .

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Pedersen, E., Bongo, L.A. (2016). Big Biological Data Management. In: Pop, F., Kołodziej, J., Di Martino, B. (eds) Resource Management for Big Data Platforms. Computer Communications and Networks. Springer, Cham. https://doi.org/10.1007/978-3-319-44881-7_13

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  • DOI: https://doi.org/10.1007/978-3-319-44881-7_13

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