Abstract
In cardiac magnetic resonance imaging, fully-automatic segmentation of the heart enables precise structural and functional measurements to be taken, e.g. from short-axis MR images of the left-ventricle. In this work we propose a recurrent fully-convolutional network (RFCN) that learns image representations from the full stack of 2D slices and has the ability to leverage inter-slice spatial dependences through internal memory units. RFCN combines anatomical detection and segmentation into a single architecture that is trained end-to-end thus significantly reducing computational time, simplifying the segmentation pipeline, and potentially enabling real-time applications. We report on an investigation of RFCN using two datasets, including the publicly available MICCAI 2009 Challenge dataset. Comparisons have been carried out between fully convolutional networks and deep restricted Boltzmann machines, including a recurrent version that leverages inter-slice spatial correlation. Our studies suggest that RFCN produces state-of-the-art results and can substantially improve the delineation of contours near the apex of the heart.
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References
Avendi, M.R., Kheradvar, A., Jafarkhani, H.: A combined deep-learning and deformable-model approach to fully automatic segmentation of the left ventricle in cardiac MRI. Med. Image Anal. 30, 108–119 (2016)
Cho, K., van Merrienboer, B., Gulcehre, C., Bahdanau, D., Bougares, F., Schwenk, H., Bengio, Y.: Learning Phrase Representations using RNN Encoder-Decoder for Statistical Machine Translation. arXiv:1406.1078 (2014)
Chung, J., Gulcehre, C., Cho, K., Bengio, Y.: Empirical Evaluation of Gated Recurrent Neural Networks on Sequence Modeling. arXiv:1412.3555 (2014)
Georgescu, B., Zhou, X.S., Comaniciu, D., Gupta, A.: Database-guided segmentation of anatomical structures with complex appearance. In: CVPR, vol. 2, pp. 429–436 (2005)
Hinton, G.E., Salakhutdinov, R.R.: Reducing the dimensionality of data with neural networks. Science 313(5786), 504–507 (2006)
Hinton, G.E., Srivastava, N., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.R.: Improving neural networks by preventing co-adaptation of feature detectors. arXiv:1207.0580 [cs] (2012)
Hochreiter, S., Schmidhuber, J.: Long short-term memory. Neural Comput. 9(8), 1735–1780 (1997)
Hu, H., Liu, H., Gao, Z., Huang, L.: Hybrid segmentation of left ventricle in cardiac MRI using Gaussian-mixture model and region restricted dynamic programming. Magn. Reson. Imaging 31(4), 575–584 (2013)
Huang, R., Pavlovic, V., Metaxas, D.N.: A graphical model framework for coupling MRFs and deformable models, vol. 2, pp. 739–746 (2004)
Huang, S., Liu, J., Lee, L.C., Venkatesh, S.K., Teo, L.L.S., Au, C., Nowinski, W.L.: An image-based comprehensive approach for automatic segmentation of left ventricle from cardiac short axis cine MR images. J. Digit. Imaging 24(4), 598–608 (2011)
Ioffe, S., Szegedy, C.: Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift. arXiv:1502.03167 [cs], February 2015
Jolly, M.: Fully automatic left ventricle segmentation in cardiac cine MR images using registration and minimum surfaces. MIDAS J. 49 (2009)
Kass, M., Witkin, A., Terzopoulos, D.: Snakes: active contour models. Int. J. Comput. Vision 1(4), 321–331 (1988)
Lewandowski, A.J., Augustine, D., Lamata, P., Davis, E.F., Lazdam, M., Francis, J., McCormick, K., Wilkinson, A.R., Singhal, A., Lucas, A., Smith, N.P., Neubauer, S., Leeson, P.: Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation 127(2), 197–206 (2013)
Li, C., Xu, C., Gui, C., Fox, M.: Distance regularized level set evolution and its application to image segmentation. IEEE Trans. Image Process. 19(12), 3243–3254 (2010)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: CVPR (2015)
Ngo, T.A., Carneiro, G.: Fully automated non-rigid segmentation with distance regularized level set evolution initialized and constrained by deep-structured inference. In: CVPR, pp. 3118–3125 (2014)
Ngo, T.A., Carneiro, G.: Left ventricle segmentation from cardiac MRI combining level set methods with deep belief networks. In: ICIP, pp. 695–699 (2013)
Ngo, T.A., Lu, Z., Carneiro, G.: Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance. Med. Image Anal. 35, 159–171 (2017)
Petitjean, C., Dacher, J.N.: A review of segmentation methods in short axis cardiac MR images. Med. Image Anal. 15(2), 169–184 (2011)
Radau, P., Lu, Y., Connelly, K., Paul, G., Dick, A.J., Wright, G.A.: Evaluation framework for algorithms segmenting short axis cardiac MRI. MIDAS J. Card. MR Left Ventricle Segmentation Challenge (2009)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: MICCAI (2015)
Sutskever, I., Hinton, G.E., Taylor, G.W.: The recurrent temporal restricted Boltzmann machine. In: NIPS, pp. 1601–1608 (2009)
Tieleman, T., Hinton, G.: Lecture 6.5-rmsprop: Divide the gradient by a running average of its recent magnitude. In: COURSERA: Neural Networks for Machine Learning, vol. 4 (2012)
Valipour, S., Siam, M., Jagersand, M., Ray, N.: Recurrent Fully Convolutional Networks for Video Segmentation. arXiv:1606.00487 [cs] (2016)
Acknowledgements
The authors would like to thank Paul Leeson and Adam Lewandowski from Oxford University for their assistance with the PRETERM dataset.
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Poudel, R.P.K., Lamata, P., Montana, G. (2017). Recurrent Fully Convolutional Neural Networks for Multi-slice MRI Cardiac Segmentation. In: Zuluaga, M., Bhatia, K., Kainz, B., Moghari, M., Pace, D. (eds) Reconstruction, Segmentation, and Analysis of Medical Images. RAMBO HVSMR 2016 2016. Lecture Notes in Computer Science(), vol 10129. Springer, Cham. https://doi.org/10.1007/978-3-319-52280-7_8
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