Skip to main content

Microaneurysm Candidate Extraction Methodology in Retinal Images for the Integration into Classification-Based Detection Systems

  • Conference paper
  • First Online:
Bioinformatics and Biomedical Engineering (IWBBIO 2017)

Abstract

Diabetic Retinopathy (DR) is one of the most common complications of long-term diabetes. It is a progressive disease that causes retina damage. DR is asymptomatic at the early stages and can lead to blindness if it is not treated in time. Thus, patients with diabetes should be routinely evaluated through systemic screening programs using retinal photography. Automated pre-screening systems, aimed at filtering cases of patients not affected by the disease using retinal images, can reduce the specialist’ workload. Since microaneurysms (MAs) appear as a first sign of DR in retina, early detection of this lesion is an essential step in automatic detection of DR. Most of MA detection systems are based on supervised classification and are designed in two stages: MA candidate extraction and further description and classification. This work proposes a method that addresses the first stage. Evaluation of the proposed method on a test dataset of 83 images shows that the method could operate at sensitivities of 74%, 82% and 87% with a number of 92, 140 and 194 false positives per image, respectively. These results show that the methodology detects low contrast MAs with the background and is suitable to be integrated in a complete classification-based MA detection system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Guariguata, L., et al.: Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res. Clin. Pract. 103(2), 137–149 (2014)

    Article  Google Scholar 

  2. Bourne, R.R., et al.: Causes of vision loss worldwide, 1990–2010: a systematic analysis. Lancet Glob. Health 1, e339–e349 (2013)

    Article  Google Scholar 

  3. Abramoff, M.D., et al.: Evaluation of a system for automatic detection of diabetic retinopathy from color fundus photographs in a large population of patients with diabetes. Diabetes Care 31(2), 193–198 (2008). doi:10.2337/dc07-1312

    Article  Google Scholar 

  4. Khan, T., et al.: Preventing diabetes blindness: cost effectiveness of a screening programme using digital non-mydriatic fundus photography for diabetic retinopathy in a primary healt care setting in South Africa. Diabetes Res. Clin. Pract. 101, 170–176 (2013)

    Article  Google Scholar 

  5. Soto-Pedre, E., Navea, A., Millan, S., Hernaez-Ortega, M.C., Morales, J., Desco, M.C., Pérez, P.: Evaluation of automated image analysis software for the detection of diabetic retinopathy to reduce the ophthalmologists’ workload. Acta Ophthalmol. 93, e52–e56 (2015). doi:10.1111/aos.12481

    Article  Google Scholar 

  6. Mane, V.M., Jadhav, D.V.: Review: progress towards automated early stage detection of diabetic retinopathy: image analysis systems and potential. J. Med. Biol. Eng. 34, 520–527 (2014)

    Google Scholar 

  7. Mookiah, M.R.K., Acharya, U.R., Chua, C.K., Lim, C.M., Ng, E.Y.K., Laude, A.: Computer-aided diagnosis of diabetic retinopathy: a review. Comput. Biol. Med. 43(12), 2136–2155 (2013)

    Article  Google Scholar 

  8. Walter, T., Massin, P., Erginay, A., Ordonez, R., Jeulin, C., Klein, J.-C.: Automatic detection of microaneurysms in color fundus images. Med. Image Anal. 11(6), 555–566 (2007)

    Article  Google Scholar 

  9. Fleming, A.D., Philip, S., Goatman, K.A., Olson, J.A., Sharp, P.F.: Automated microaneurysm detection using local contrast normalization and local vessel detection. IEEE Trans. Med. Imaging 25(9), 1223–1232 (2006)

    Article  Google Scholar 

  10. Quellec, G., Lamard, M., Josselin, P.M., Cazuguel, G., Cochener, B., Roux, C.: Optimal wavelet transform for the detection of microaneurysms in retina photographs. IEEE Trans. Med. Imaging 27(9), 1230–1241 (2008)

    Article  Google Scholar 

  11. Hipwell, J.H., Strachan, F., Olson, J.A., McHardy, K.C., Sharp, P.F., Forrester, J.V.: Automated detection of microaneurysms in digital red-free photographs: a diabetic retinopathy screening tool. Diabetic Med. 17(8), 588–594 (2000)

    Article  Google Scholar 

  12. Antal, B., Hajdu, A.: An ensemble-based system for microaneurysm detection and diabetic retinopathy grading. IEEE Trans. Biomed. Eng. 59(6), 1720–1726 (2012)

    Article  Google Scholar 

  13. Oliveira, J., Minas, G., Silva, C.: Automatic detection of microaneurysm based on the slant stacking. In: Proceedings of the 26th IEEE International Symposium on Computer-Based Medical Systems, Porto, pp. 308–313 (2013). doi:10.1109/CBMS.2013.6627807

  14. Hatanaka, Y., Inoue, T., Okumura, S., Muramatsu, C., Fujita, H.: Automated microaneurysm detection method based on double ring filter and feature analysis in retinal fundus images. IEEE (2012). ISBN: 978-1-4673- 2051-1

    Google Scholar 

  15. Lazar, I., Hajdu, A.: Retinal microaneurysm detection through local rotating cross-section profile analysis. IEEE Trans. Med. Imaging. 32(2), 400–407 (2013)

    Article  Google Scholar 

  16. Javidi, M., et al.: Vessel segmentation and microaneurysm detection using discriminative dictionary learning and sparse representation. Comput. Methods Programs Biomed. 139 93–108 (2016)

    Article  Google Scholar 

  17. Ganjee, R., Azmi, R., Ebrahimi Moghadam, M.: J. Med. Syst. 40, 74 (2016). doi:10.1007/s10916-016-0434-4

    Article  Google Scholar 

  18. Marín, D., Aquino, A., Gegúndez-Arias, M.E., Bravo, J.M.: A new supervised method for blood vessel segmentation in retinal images by using gray-level and moment invariants-based features. IEEE Trans. Med. Imaging 30(1), 146–158 (2011)

    Article  Google Scholar 

  19. Marin, D., et al: Obtaining optic disc center and pixel region by automatic thresholding methods on morphologically processed fundus images. Comput. Methods Programs Biomed. 118(2), 173–185 (2015). http://dx.doi.org/10.1016/j.cmpb.2014.11.003

  20. Gegúndez-Arias, M., Marin, D., Bravo, J., Suero, A.: Locating the fovea center position in digital fundus images using thresholding and feature extraction techniques. Comp. Med. Imaging Graph. 37(5–6), 386–393 (2013)

    Article  Google Scholar 

  21. Chakraborty, D.P.: Clinical relevance of the ROC and free response paradigms for comparing imaging system efficacies. Radiat. Prot. Dosimetry 139(1–3), 37–41 (2010)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Estefanía Cortés-Ancos .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Cortés-Ancos, E., Gegúndez-Arias, M.E., Marin, D. (2017). Microaneurysm Candidate Extraction Methodology in Retinal Images for the Integration into Classification-Based Detection Systems. In: Rojas, I., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science(), vol 10208. Springer, Cham. https://doi.org/10.1007/978-3-319-56148-6_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-56148-6_33

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56147-9

  • Online ISBN: 978-3-319-56148-6

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics