Abstract
Are analyzed the experimental data on fluorescing DNA complexes inside neutrophils in flow cytometry with nanometer spatial resolution. Fluorescence visualizes oxidative activity of all coding and non-coding DNA in the full set of chromosomes. The oxidative and information activity of DNA and corresponding Shannon entropies are packed in different ultra dense fractal networks of ‘exponentially small worlds’. Different types of oxidative and information activity of DNA are characterized by rather strong fluctuations and intermittent behavior, typical for irregular, rare strong flashes of rare events. The negative covariance of oxidative and information activity of DNA provide self-regulation of informational homeostasis of DNA complex in all aerobic cells, i.e. the identical values of the total Shannon entropy for information activity of DNA complex in networks of different ranks. Thus, flexible changeability of DNA complex inside cells with respect to different perturbations of DNA activity defines compatibility and stable coexistence of different cells in the life of all aerobic beings. Different collective distributions and large scale networks of DNA activity reflect the state of health of the given person at a given time.
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References
Bassoe, C.-F., Li, N., Ragheb, K., Lawler, G., Sturgis, J., Robinson, J.P.: Investigations of phagosomes, mitochondria, and acidic granules in human neutrophils using fluorescent probes. Cytom. B Clin. Cytom. 51B, 21–29 (2002)
Filatov, M.V., Varfolomeeva, E.Y., Ivanov, E.A.: Flow cytofluorometric detection of inflammatory processes by respiratory burst reaction of peripheral blood neutrophils. Biochem. Mol. Med. 55, 116–123 (1995)
Shapiro, H.: Practical Flow Cytometry. Wiley, New York (2003)
Galich, N.E.: Shannon-weaver biodiversity of neutrophils in fractal networks of immunofluorescence for medical diagnostics. J. WASET 4, 446–457 (2010)
Galich, N.E.: Bifurcations of averaged immunofluorescence distributions due to oxidative activity of DNA in medical diagnostics. Biophys. Rev. Lett. 5, 227–240 (2010)
Galich, N.E.: How chromosomal correlations form a single information complex DNA inside living cells? Intermittency of informational connections DNA. Appl. Math. Sci. 9, 2657–2670 (2015)
Galich, N.E.: Intermittency and changing stability of oxidative activity of DNA in chromosomes inside cells. Biophys. Rev. Lett. 10, 187–199 (2015)
Galich, N.E.: Complex networks, fractals and topology trends for oxidative activity of DNA in cells for populations of fluorescing neutrophils in medical diagnostics. Phys. Procedia 22, 177–185 (2011)
Feder, J.: Fractals. Plenum Press, New York (1988)
Galich, N.E.: Fractal networks of real worlds of fluorescing DNA in complete set of chromosomes inside blood cells for medical diagnostics. Open J. Biophys. 3, 232–244 (2013)
Galich, N.E.: Dense fractal networks, trends, noises and switches in homeostasis regulation of Shannon entropy for chromosomes’ activity in living cells for medical diagnostics. Appl. Math. Chaos Fractal 4(11B), 30–41 (2013)
Newman, M.E.J.: The structure and function of complex networks. SIAM Rev. 45, 167–256 (2003)
Rybalko, S., Larionov, S., Poptsova, M., Loskutov, A.: Intermittency as a universal characteristic of the complete chromosome DNA sequences of eukaryotes: from protozoa to human genomes. Phys. Rev. E 84, 042902-1-5 (2011)
Vaya, I., Gustavsson, T., Miannay, F.-A., Douki, T., Markovitsi, D.: Fluorescence of natural DNA: from the femtosecond to the nanosecond time scales. J. Am. Chem. Soc. 132(34), 11834–11835 (2010)
Hogan, M., Wang, L., Austin, R.H., Monitto, C.I., Hershkow, S.: Biophysics molecular motion of dna as measured by triplet anisotropy decay (flexible rod/local motion). PNAS 79, 3518–3522 (1982)
Sabanayagam, C.R., Eid, J.S., Mellera, A.: Long time scale blinking kinetics of cyanine fluorophores conjugated to DNA and its effect on Förster resonance energy transfer. J. Chem. Phys. 123, 224708-1-7 (2005)
Klevecz, R.R., Kapp, L.N.: Intermittent DNA synthesis and periodic expression of enzyme activity in cell cycle of WI-38. J. Cell Biol. 58, 564–573 (1973)
Zeldovich, Y.A.B., Molchanov, S.A., Ruzmaikin, A.A., Sokolov, D.D.: Intermittency in random media. Sov. Phys. Usp. 30, 353–369 (1987)
Nakao, H., Mikhailov, A.S.: Statistics of rare strong bursts in autocatalytic stochastic growth with diffusion. Chaos 13, 953–961 (2003)
Galich, N.E.: Invariance and noises of Shannon entropy for information on oxidative activity of DNA in all living cells for medical diagnostics. Am. J. Oper. Res. 4, 72–89 (2014)
Galich, N.E.: Self-regulation of information complexes DNA in hierarchy networks of Shannon entropy inside living cells. AASRI Procedia 9, 123–130 (2014)
Galich, N.E.: Dense patterns, switching, stability and self-regulation in information networks DNA inside living cells. IERI Procedia 10, 25–31 (2014)
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Thanks for providing the experimental data of M. Filatov.
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Galich, N.E. (2018). Self-regulation and Covariance of Intermittent DNA Activity in the Major Networks Inside Cells. In: Bi, Y., Kapoor, S., Bhatia, R. (eds) Proceedings of SAI Intelligent Systems Conference (IntelliSys) 2016. IntelliSys 2016. Lecture Notes in Networks and Systems, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-56994-9_77
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DOI: https://doi.org/10.1007/978-3-319-56994-9_77
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