Abstract
Hippocampus is a region in the mammalian brain largely responsible for short term memory and spatial navigation. In this paper we present a model to simulate a part of hippocampus called CA3b. We show that our model is capable of producing waveforms in Theta rhythm range. Then, we introduce two types of lesions in the structure and analyze their effect on the collective behavior of neurons in CA3b.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Andersen, P.: The Hippocampus Book. Oxford Neuroscience Series. Oxford University Press, Oxford (2007)
Borich, M., Babul, A.N., Hsiang, Y.P., Boyd, L., Virji-Babul, N.: Alterations in resting-state brain networks in concussed adolescent athletes. J. Neurotrauma 32(4), 265–271 (2015)
Cohen, I., Miles, R.: Contributions of intrinsic and synaptic activities to the generation of neuronal discharges in in vitro hippocampus. J. Physiol. 524(2), 485–502 (2000)
Colgin, L.L.: Mechanisms and functions of theta rhythms. Annu. Rev. Neurosci. 36(1), 295–312 (2013)
Cutsuridis, V., Graham, B., Cobb, S., Vida, I.: Hippocampal Microcircuits: A Computational Modeler’s Resource Book. Springer Series in Computational Neuroscience. Springer, Heidelberg (2010)
Dimopoulos, N.: A study of the asymptotic behavior of neural networks. IEEE Trans. Circ. Syst. 36(5), 687–694 (1989)
Dimopoulos, N.J., Newcomb, R., Smith, M.: Some observations on oscillations in neural type networks. In: Proceedings of 33rd Annual Conference on Engineering in Medicine and Biology, p. 64 (1980)
Gewaltig, M.O., Diesmann, M.: Nest (neural simulation tool). Scholarpedia 2(4), 1430 (2007)
Goutagny, R., Jackson, J., Williams, S.: Self-generated theta oscillations in the hippocampus. Nat. Neurosci. 12(12), 1491–1493 (2009)
Hardie, J.B., Pearce, R.A.: Active and passive membrane properties and intrinsic kinetics shape synaptic inhibition in hippocampal CA1 pyramidal neurons. J. Neurosci. 26(33), 8559–8569 (2006)
Kadmon, J., Sompolinsky, H.: Transition to chaos in random neuronal networks. Phys. Rev. X 5, 041030 (2015)
Keshavarz-Hedayati, B., Dimopoulos, N.J., Babul, A.: An analysis of dynamics of CA3b in hippocampus. In: 2014 International Conference on Embedded Computer Systems: Architectures, Modeling, and Simulation (SAMOS XIV), pp. 375–383 July 2014
Konopacki, J.: Theta-like activity in the limbic cortex in vitro. Neurosci. Biobehav. Rev. 22(2), 311–323 (1998)
Leao, R.N., Mikulovic, S., Leao, K.E., Munguba, H., Gezelius, H., Enjin, A., Patra, K., Eriksson, A., Loew, L.M., Tort, A.B.L., Kullander, K.: OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat. Neurosci. 15(11), 1524–1530 (2012)
Leung, L.S.: Generation of theta and gamma rhythms in the hippocampus. Neurosci. Biobehav. Rev. 22(2), 275–290 (1998)
Pignatelli, M., Beyeler, A., Leinekugel, X.: Neural circuits underlying the generation of theta oscillations. J. Physiol.-Paris 106(34), 81–92 (2012)
Rennó-Costa, C., Lisman, J.E., Verschure, P.F.: A signature of attractor dynamics in the CA3 region of the hippocampus. PLoS Comput. Biol. 10, e1003641 (2014)
Roux, F., Uhlhaas, P.J.: Working memory and neural oscillations: alpha-gamma versus theta-gamma codes for distinct WM information? Trends Cogn. Sci. 18(1), 16–25 (2014)
Szatmáry, B., Izhikevich, E.M.: Spike-timing theory of working memory. PLoS Comput. Biol. 6(8), 1–11 (2010)
Traub, R.D., Wong, R.K., Miles, R., Michelson, H.: A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J. Neurophysiol. 66(2), 635–650 (1991)
Traub, R., Miles, R.: Neuronal Networks of the Hippocampus, vol. 777. Cambridge University Press, Cambridge (1991)
Traub, R.D., Bibbig, A., Fisahn, A., LeBeau, F.E.N., Whittington, M.A., Buhl, E.H.: A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro. Eur. J. Neurosci. 12(11), 4093–4106 (2000)
Zenke, F., Agnes, E.J., Gerstner, W.: Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks. Nat. Commun. 6 (2015). Article no. 6922
Acknowledgment
Computational support was provided by Compute Canada through WestGrid and the HPC Facility at the University of Victoria. This work was supported in part by The Natural Sciences and Engineering Research Council of Canada (NSERC) and by the Lansdowne Chair in Computer Engineering at the University of Victoria. We would like to thank the nest-initiative for their support in usage of NEST, and Dr. Naznin Virji-Babul for her many insights.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Keshavarz-Hedayati, B., Dimopoulos, N., Babul, A. (2017). A Study on the Effects of Lesions on CA3b in Hippocampus. In: Cong, F., Leung, A., Wei, Q. (eds) Advances in Neural Networks - ISNN 2017. ISNN 2017. Lecture Notes in Computer Science(), vol 10262. Springer, Cham. https://doi.org/10.1007/978-3-319-59081-3_55
Download citation
DOI: https://doi.org/10.1007/978-3-319-59081-3_55
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-59080-6
Online ISBN: 978-3-319-59081-3
eBook Packages: Computer ScienceComputer Science (R0)