Abstract
Automatic segmentation of prostate gland in magnetic resonance (MR) images is a challenging task due to large variations of prostate shapes and indistinct boundaries with adjacent tissues. In this paper, we propose an automatic pipeline to segment prostate gland in diffusion magnetic resonance images (dMRI). The most common approach for segmenting prostate in MR images is based on image registration, which is computationally expensive and solely relies on the pre-segmented images (also known as atlas). In contrast, the proposed method uses a clustering method applied to the dMRI to separate prostate gland from the surrounding tissues followed by a postprocessing stage via active contours. The proposed pipeline was validated on prostate MR images of 25 patients and the segmentation results were compared to manually delineated prostate contours. The proposed method achieves an overall accuracy with mean Dice Similarity Coefficient (DSC) of 0.84\(\ \pm \ \)0.04, while being the most effective in the middle prostate gland producing a mean DSC of 0.91\(\ \pm \ \)0.03. The proposed method has the potential to be integrated into clinical decision support systems that aid radiologists in monitoring prostate cancer.
F. Khalvati—This work was partially supported by Ontario Institute of Cancer Research (OICR) and Cancer Care Ontario (CCO) - Imaging Network of Ontario (CINO).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Canadian Cancer Statistics: Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Toronto, ON: Canadian Cancer Society (2016)
Roehrborn, C.G., et al.: Serum prostate-specific antigen and prostate volume predict long-term changes in symptoms and flow rate: results of a four-year, versus placebo. Urology 54(4), 662–669 (1999)
Huyskens, D.P., Salamon, E., et al.: A qualitative and a quantitative analysis of an auto-segmentation module for prostate cancer. Radiother. Oncol. 90(3), 337–345 (2009)
Mahapatra, D., Buhmann, J.: Prostate MRI Segmentation using learned semantic knowledge and graph cuts. IEEE Trans. Biomed. Eng. 61(3), 756–764 (2014)
Klein, S., et al.: Automatic segmentation of the prostate in 3D MR images by atlas matching using localized mutual information. Med. Phys. 35, 1407–1417 (2008)
Toth, R., et al.: Accurate prostate volume estimation using multifeature active shape models on T2-weighted MRI. Acad. Radiol. 18(6), 745–754 (2011)
Moschidis, E., Graham, J.: Automatic differential segmentation of the prostate in 3-D MRI using random forest classification and graph-cuts optimization. In: IEEE ISBI, pp. 1727–1730 (2012)
Litjens, G., et al.: Evaluation of prostate segmentation algorithms for MRI: the PROMISE12 challenge. Med. Image Anal. 18(2), 359–373 (2014)
Dempster, A., Larid, N., Rubin, D.: Maximum likelihood from incomplete data via the EM algorithm. J. R. Stat. Soc. 39(1), 1–38 (1977)
Caselles, V., Kimmel, R., Sapiro, G.: Geodesic active contours. Int. J. Comput. Vis. 22, 61–79 (1997)
Zhang, J., Baig, S., Wong, A., Haider, M.A., Khalvati, F.: A local ROI-specific atlas-based segmentation of prostate gland and transitional zone in diffusion MRI. J. Comput. Vis. Imaging Syst. 2(1) (2016)
Bharatha, A., Hirose, M., Hata, N., Warfield, S.K., Ferrant, M., Zou, K.H., Suarez-santana, E., Ruiz-Alzola, J., D’Amico, A., Cormack, R.A., Kikinis, R., Jolesz, F.A., Tempany, C.M.C.: Evaluation of three-dimensional finite element-based deformable registration of pre- and intra-operative prostate imaging. Med. Phys. 28(12), 2551–2560 (2001)
Khalvati, F., Salmanpour, A., Rahnamayan, S., Rodrigues, G., Tizhoosh, H.R.: Inter-slice bidirectional registration-based segmentation of the prostate gland in MR and CT image sequences. Med. Phys. 40(12), 123503-1-11 (2013)
Khalvati, F., Salmanpour, A., Rahnamayan, S., Haider, M.A., Tizhoosh, H.R.: Sequential registration-based segmentation of the prostate gland in MR image volumes. J. Digit. Imaging 29(2), 254–263 (2016)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Zhang, J., Baig, S., Wong, A., Haider, M.A., Khalvati, F. (2017). Segmentation of Prostate in Diffusion MR Images via Clustering. In: Karray, F., Campilho, A., Cheriet, F. (eds) Image Analysis and Recognition. ICIAR 2017. Lecture Notes in Computer Science(), vol 10317. Springer, Cham. https://doi.org/10.1007/978-3-319-59876-5_52
Download citation
DOI: https://doi.org/10.1007/978-3-319-59876-5_52
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-59875-8
Online ISBN: 978-3-319-59876-5
eBook Packages: Computer ScienceComputer Science (R0)