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2DIs: A SBML Compliant Web Platform for the Design and Modeling of Immune System Interactions

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Intelligent Computing Theories and Application (ICIC 2017)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 10362))

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Abstract

We present 2DIs, a web platform that allows the easy design of extracellular models of the immune system function, including the possibility to describe the most important immune system entities and interactions and to produce a validated SBML file of the model. 2DIs permits immunologists to directly describe and share their knowledge with other colleagues and, more importantly, with modelers that can therefore obtain an SBML-compliant modelling template of the immunological process that can be used to develop the computational model. This could introduce a novel way of communicating among immunologists and modelers, reducing the risk of errors and misinterpretations.

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References

  1. Hucka, M., Finney, A., Sauro, H.M., Bolouri, J.H., Doyle, C., Kitano, H., Arkin, A.P., Bornstein, B.J., Bray, D., Cornish-Bowden, A.: The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19(4), 524–531 (2003)

    Article  Google Scholar 

  2. Hoops, S., Sahle, S., Gauges, R., Lee, C., Pahle, J., Simus, N.: COPASI—a COmplex PAthway Simulator. Bioinformatics 22, 3067–3074 (2006)

    Article  Google Scholar 

  3. Funahashi, A., Morohashi, M., Kitano, H., Tanimura, N.: CellDesigner: a process diagram editor for gene-regulatory and biochemical networks. Biosilico 1(5), 159–162 (2003)

    Article  Google Scholar 

  4. Köhler, J., Baumbach, J., Taubert, J., Specht, M., Skusa, A., Rüegg, A., Rawlings, C., Verrier, P., Philippi, S.: Graph-based analysis and visualization of experimental results with ONDEX. Bioinformatics 22, 1383–1390 (2006)

    Article  Google Scholar 

  5. Shannon, P., Markiel, A., Ozier, O., Baliga, N.S., Wang, J.T., Ramage, D., Amin, N., Schwikowski, B., Ideker, T.: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498–2504 (2003)

    Article  Google Scholar 

  6. Rojas, I., Golebiewski, M., Kania, R., Krebs, O., Mir, S., Weidemann, A., Wittig, U.: Storing and annotating of kinetic data. In Silico Biol. 7, 37–44 (2007)

    Google Scholar 

  7. Pappalardo, F., Forero, I.M., Pennisi, M., Palazon, A., Melero, I., Motta, S.: SimB16: modeling induced immune system response against B16-melanoma. PLoS ONE 6(10), e26523 (2011)

    Article  Google Scholar 

  8. Pennisi, M.: A mathematical model of immune system-melanoma competition. Comput. Math. Methods Med., Article ID 850754, 13 p. (2012)

    Google Scholar 

  9. Heiner, M., Herajy, M., Liu, F., Rohr, C., Schwarick, M.: Snoopy – a unifying Petri Net tool. In: Haddad, S., Pomello, L. (eds.) PETRI NETS 2012. LNCS, vol. 7347, pp. 398–407. Springer, Heidelberg (2012). doi:10.1007/978-3-642-31131-4_22

    Chapter  Google Scholar 

  10. Pennisi, M., Cavalieri, S., Motta, S., Pappalardo, F.: A methodological approach for using High-Level Petri Nets to model the adaptive immune system response. BMC Bioinf. 17(Suppl 19), 498 (2016). doi:10.1186/s12859-016-1361-6

    Article  Google Scholar 

  11. Murata, T.: Petri Nets: properties, analysis and applications. Proc. IEEE 77(4), 541–580 (1989)

    Article  Google Scholar 

  12. Bianca, C., Chiacchio, F., Pappalardo, F., Pennisi, M.: Mathematical modeling of the immune system recognition to mammary carcinoma antigen. BMC Bioinf. 13(Suppl 17), S21 (2012). doi:10.1186/1471-2105-13-S17-S21

    Article  Google Scholar 

  13. Pappalardo, F., Fichera, E., Paparone, N., Lombardo, A., Pennisi, M., Russo, G., Leotta, M., Pappalardo, F., Pedretti, A., De Fiore, F., Motta, S.: A computational model to predict the immune system activation by citrus-derived vaccine adjuvants. Bioinformatics 32(17), 2672–2680 (2016)

    Article  Google Scholar 

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Correspondence to Francesco Pappalardo .

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Pennisi, M., Russo, G., Sgroi, G., Parasiliti, G., Pappalardo, F. (2017). 2DIs: A SBML Compliant Web Platform for the Design and Modeling of Immune System Interactions. In: Huang, DS., Jo, KH., Figueroa-García, J. (eds) Intelligent Computing Theories and Application. ICIC 2017. Lecture Notes in Computer Science(), vol 10362. Springer, Cham. https://doi.org/10.1007/978-3-319-63312-1_13

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  • DOI: https://doi.org/10.1007/978-3-319-63312-1_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-63311-4

  • Online ISBN: 978-3-319-63312-1

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