Abstract
With the development of proteomics and cell biology, protein sub-cellular location has become a hot topic in bioinformatics. As the time goes on, more and more researchers make great efforts on studying protein sub-cellular location. But they only do research on single-site protein sub-cellular location. However, some proteins can belong to two or more sub-cellulars. So, we should transfer the line of sight to multisite protein sub-cellular location. In this article, we use Virus-mPLoc data set and choose pseudo amino acid composition and correlation coefficient two effective feature extraction methods. Then, putting these features into multi-label k-nearest neighbor classifier to predict protein sub-cellular location. The experiment proves that this method is reasonable and the precision reached 68.65% through the Jack-knife test.
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Acknowledgment
This research was supported by the National Key Research And Development Program of China (No. 2016YFC0106000), National Natural Science Foundation of China (Grant No. 61302128, 61573166, 61572230, 61671220, 61640218), the Youth Science and Technology Star Program of Jinan City (201406003), the Natural Science Foundation of Shandong Province (ZR2013FL002), the Shandong Distinguished Middle-aged and Young Scientist Encourage and Reward Foundation, China (Grant No. ZR2016FB14), the Project of Shandong Province Higher Educational Science and Technology Program, China (Grant No. J16LN07), the Shandong Province Key Research and Development Program, China (Grant No. 2016GGX101022).
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Wu, P., Wang, D., Zhong, XF., Zhao, Q. (2017). Predicting Multisite Protein Sub-cellular Locations Based on Correlation Coefficient. In: Huang, DS., Jo, KH., Figueroa-GarcÃa, J. (eds) Intelligent Computing Theories and Application. ICIC 2017. Lecture Notes in Computer Science(), vol 10362. Springer, Cham. https://doi.org/10.1007/978-3-319-63312-1_67
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DOI: https://doi.org/10.1007/978-3-319-63312-1_67
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