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Analyses of the Dual Immune Roles Cytokines Play in Ischemic Stroke

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Health Information Science (HIS 2017)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 10594))

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Abstract

Stroke is one of the leading causes of morbidity and permanent disability worldwide. There is a need for an efficacious alternative therapy administered beyond the limitation of time window based on the biological characteristics of stroke, currently. The immunomodulatory therapy could extend the time window while not increase the risk of hemorrhage which made it become candidate treatments. In this paper, we integrated several gene expression profiles generated from the peripheral blood of ischemic stroke patients and health people. Differential expressed cytokines were first selected as candidate cytokines. Enrichment analyses were then performed to filter the candidate cytokines as biomarkers (E-CKs) by checking the relationships between them and the stroke related functional terms. More cytokines were found as biomarkers in the sub-acute stage of ischemic stroke compared with acute and chronic stages which could be explained by the great changes in microenvironment in this necrosis stage. Analyses based on microRNomics level showed that more E-CKs one miRNA regulated, the more important role it played in stroke related processes. Similarly, analyses on proteomics level showed that E-CKs with top degrees in the protein-protein interaction network were proved to be closely related to stroke. Most E-CKs participate in both the stroke processing and rehabilitation, thus, the dual immune characters made them become valuable potential targets of immunomodulatory therapies.

Y. Wang and J. Liu contributed equally to this paper.

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Author information

Authors and Affiliations

  1. Research Center for Biomedical Information Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Yingying Wang & Yunpeng Cai

  2. Shenzhen Engineering Laboratory of Health Big Data Analyses Technology, Shenzhen, China

    Yingying Wang & Yunpeng Cai

  3. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China

    Jianfeng Liu

  4. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China

    Haibo Yu

Authors
  1. Yingying Wang
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  2. Jianfeng Liu
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  3. Haibo Yu
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  4. Yunpeng Cai
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Corresponding author

Correspondence to Yunpeng Cai .

Editor information

Editors and Affiliations

  1. Centre for Applied Informatics, Victoria University, Melbourne, Victoria, Australia

    Siuly Siuly

  2. Vrije University of Amsterdam, Amsterdam, The Netherlands

    Zhisheng Huang

  3. University of Nottingham, Nottingham, United Kingdom

    Uwe Aickelin

  4. Swinburne University of Technology, Melbourne, Victoria, Australia

    Rui Zhou

  5. Victoria University, Melbourne, Victoria, Australia

    Hua Wang

  6. Victoria University, Melbourne, Victoria, Australia

    Yanchun Zhang

  7. Institute for High Energy Physics, Protvino, Russia

    Stanislav Klimenko

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Wang, Y., Liu, J., Yu, H., Cai, Y. (2017). Analyses of the Dual Immune Roles Cytokines Play in Ischemic Stroke. In: Siuly, S., et al. Health Information Science. HIS 2017. Lecture Notes in Computer Science(), vol 10594. Springer, Cham. https://doi.org/10.1007/978-3-319-69182-4_12

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  • DOI: https://doi.org/10.1007/978-3-319-69182-4_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-69181-7

  • Online ISBN: 978-3-319-69182-4

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