Abstract
Alcohol dependence syndrome has been associated to disfunctions of the pre-frontal cortex, with a negative impact on several areas of cognitive functioning, such as attention, memory and learning, visual-spatial synthesis, executive functions, and psychomotor functions. These changes in turn contribute to the perpetuation of the addictive behavior. We report a study with 249 recovering alcoholics assessed with neuropsychological tests pre- and post-treatment at an alcoholism rehab clinic, with follow-up for abstinence 3 and 6 months after treatment. We found that 3-month abstinence was associated to speed of psychomotor processing, whereas 6-month abstinence was related with decision-making, (lack of) impulsivity, speed of psychomotor processing, and emotional adjustment.
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References
Zampronio, A.: Prevenção ao uso de drogas. Uma Acção educativa. O caso de Jataizinnho – PR. Curitiba (2011)
Organização Mundial da Saúde: Neurociências: consumo e dependência de substâncias psicoativas - Resumo. OMS, Geneva (2004)
World Health Organization: Global Status report on alcohol and health (2014). http://www.who.int/substance_abuse/publications/global_alcohol_report/msb_gsr_2014_1.pdf?ua=1
Linneberg, A., Gonzalez-Quintela, A., Vidal, C., Jørgensen, T., Fenger, M., Hansen, T., Pedersen, O., Husemoen, L.: Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clin. Exp. Allergy 40(1), 123–130 (2010). doi:10.1111/j.1365-2222.2009.03398.x.v
Stuart, G.W., Laraia, M.T.: Enfermagem Psiquiátrica, 4th edn. Rio de Janeiro (2002)
Di Chiara, G.: The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend. 38, 95–137 (1995)
Di Chiara, G.: Alcohol and dopamine. Alcohol World Health Res. 21, 108–113 (1997)
Stahl, S.: Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects. J. Affect. Disord. 51, 215–235 (1998). http://dx.doi.org/10.1016/S0165-0327(98)00221-3
Lovinger, D.: Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn-Schmiedeberg’s Arch. Pharmacol. 356(3), 267–282 (1997)
Andrade, A., Cruz, M.: Alcoolismo: recursos terapêuticos e agentes farmacológicos promissores. Jornal Brasileiro de Psiquiatria 54(4), 270–276 (2005)
Kuhn, J., Lenartz, D., Huff, W., Lee, S., Koulousakis, A., Klosterkoetter, J., et al.: Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications? J. Neurol. Neurosurg. Psychiatry 78(10), 1152–1153 (2007). doi:10.1136/jnnp.2006.113092
Christopher, P., Vassoler, F.: Deep brain stimulation for the treatment of addiction: basic and clinical studies and potential mechanisms of action. Psychopharmacology 229(3), 487–491 (2013). doi:10.1007/s00213-013-3214-6
Kuhn, J., Grundler, T., Lenartz, D., Sturm, V., Klosterkotter, J., Huff, W.: Deep brain stimulation for psychiatric disorders. Deutsches Ärzteblatt International 107(7), 105–113 (2010)
Sankar, T., Tierney, T., Hamani, C.: Novel applications of deep brain stimulation. Surg. Neurol. Int. 14(3), s26–s33 (2012)
Heckmann, W., Silveira, C.: Dependência do álcool: aspectos clínicos e diagnósticos. In: Andrade, A., Anthony, J. (eds.) Álcool e suas conseqüências: uma abordagem multiconceitual, pp. 67–88. Editora Editora Manole Ltda, Brasil (2009)
Allen, D., Goldstein, G., Seaton, B.: Cognitive rehabilitaion of chronic alcohol abusers. Neuropsychol. Rev. 7(1), 21–39 (1997)
Cunha, P., Novaes, M.: Avaliação neurocognitiva no abuso e dependência do álcool: implicações para o tratamento. Revista Brasileira de Psiquiatria 26(1), 23–27 (2004)
Fals-Stewart, W., Lam, W.: Computer-assisted cognitive rehabilitation for the treatment of patients with substance use disorders: a randomized clinical trial. Exp. Clin. Psychopharmacol. 18(1), 87–98 (2010). doi:10.1037/a0018058
Goldstein, G., Haas, G., Shemansky, J., Barnett, B., Salmon-Cox, S.: Rehabilitation during alcohol detoxication in comorbid neuropsychiatric patients. J. Rehabil. Res. Dev. 42(2), 225–234 (2005)
Grohman, K., Fals-Stewart, W.: Computer-assisted cognitive rehabilitation with substance-abusing patients: effects on treatment response. J. Cogn. Rehabil. 21(4), 10–17 (2003)
Gruber, S., Yurgelun-Todd, D.: Neuropsychological correlates of drug abuse. In: Kaufman, M. (ed.). Brain Imaging in Substance Abuse: Research, Clinical and Forensic Applications, Chap. 7, pp. 199–209. Humana Press, New Jersey (2001). doi:10.1007/978-1-59259-021-6_7
Oliveira, M., Laranjeira, R., Jaeger, A.: O estudo dos projectos cognitivos na dependência do álcool. Psicologia, Saúde e Doenças 3(2), 205–2012 (2002)
Peterson, M., Patterson, B., Pillman, B., Battista, M.: Cognitive recovery following alcohol detoxification: a computerized remediation study. Neuropsychol. Rehabil. 12(1), 63–74 (2002)
Yohman, T., Schaeffer, K., Parsons, O.: Cognitive training in alcoholic men. J. Consult. Clin. Psychol. 56(1), 67–72 (1988)
Gamito, P., Oliveira, J., Lopes, P., Brito, R., Morais, D., Silva, D., Silva, A., Rebelo, S., Bastos, M., Deus, A.: Executive functioning in alcoholics following an mHealth cognitive stimulation program: randomized controlled trial. J. Med. Internet Res. 16(4), e102 (2014). doi:10.2196/jmir.2923
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing, Arlington (2013)
Moselhy, H., Georgiou, G., Kahn, A.: Frontal lobe changes in alcoholism: a review of the literature. Alcohol Alcohol. 36(5), 357–368 (2001). http://dx.doi.org/10.1093/alcalc/36.5.357
Bechara, A., Damásio, A.R., Damásio, H., Anderson, S.W.: Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50(1–3), 7–15 (1994)
Dalley, J., Everitt, B., Robbins, T.: Impulsivity, compulsivity, and top-down cognitive control. Neuron Rev. 69, 680–694 (2011)
Sun, H., Cocker, P., Zeeb, F., Winstanley, C.: Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. Psychopharmacology 219, 285–301 (2012)
Fisher, C., Fontes, M.: A impulsividade e o processo de tomada de decisão. Clínica Plenamente. Acedido a 17 de Maio de 2016 (2006). http://www.plenamente.com.br/artigo/181/-impulsividade-processo-tomada-decisaoclaudia-petlik.php#.Utw3FRCp1di
Bechara, A.: Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nat. Neurosci. Neurobiol. Addict. 8(11), 1458–1463 (2005)
Parsons, O.A.: Neurocognitive deficits in alcoholics and social drinkers: a continuum? Alcohol. Clin. Exp. Res. 22(4), 954–961 (1998)
Blume, A., Marlatt, G., Schmaling, K.: Memory, executive cognitive function, and readiness to change drinking behavior. Addict. Behav. 30(2), 301 (2005)
Rigoni, M., Oliveira, M., Susin, N., Sayago, C., Feldens, A.: Prontidão para mudança e alterações das funções cognitivas em alcoolistas. Psicologia em estudo 14(4), 739–747 (2005). http://dx.doi.org/10.1590/S1413-73722009000400014
Oliveira, J., Bento, B., Gamito, P., Lopes, P., Brito, R., Morais, D., Gameiro, F.: Cognitive stimulation of alcoholics through VR-based Instrumental Activities of Daily Living. ACM Digital Library, pp. 14–17 (2015). doi:10.1145/2838944.2838948
Wechsler, D.: Wechsler Memory Scale - Third edition manual. Psychological Corporation, San Antonio (1987)
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., Curtiss, G.: Wisconsin card sorting test (WCST) — manual revised and expanded. Psychological Assessment Resources, Odessa (1993)
Whiteside, S.P., Lynam, D.R.: The five factor model and impulsivity: Using a structural model of personality to understand impulsivity. Personality Individ. Differ. 30, 669–689 (2001)
Lopes, P., Oliveira, J., Brito, R., Gamito, P., Rosa, P., Trigo, H.: UPPS-P, versão portuguesa. Universidade Lusófona de Humanidades e Tecnologias, Lisboa (2013)
Derogatis, L.R., Savitz, K.L.: The SCL-90-R and the Brief Symptom Inventory (BSI) in Primary Care. In: Maruish, M.E. (ed.) Handbook of Psychological Assessment in Primary Care Settings, vol. 236, pp. 297–334. Lawrence Erlbaum Associates, Mahwah (2000)
Beck, A., Steer, R., Brown, G.: Manual for the Beck Depression Inventory II. Psychological Corporation, San Antonio (1996)
Martins, A., Coelho, R., Ramos, E., Barros, H.: Administração do BDI-II a adolescentes portugueses: resultados preliminares. Rev. Port. Psicossomática 2(1), 123–132 (2000)
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The authors would like to thank Susana Carreiro for her contribution to the collection of the post-treatment sample.
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Bento, B. et al. (2017). Neuropsychological Predictors of Alcohol Abtinence Following a Detoxification Program. In: Fardoun, H., R. Penichet, V., Alghazzawi, D., De la Guia, M. (eds) ICTs for Improving Patients Rehabilitation Research Techniques. REHAB 2015. Communications in Computer and Information Science, vol 665. Springer, Cham. https://doi.org/10.1007/978-3-319-69694-2_13
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DOI: https://doi.org/10.1007/978-3-319-69694-2_13
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