Abstract
The first aim of the paper is to investigate whether the very promising method of data analysis (the Big Data Analysis, further called BDA) – used now across various domains – can serve for information technologies in medicine, in the area of planning pathways of organic syntheses. The eventual usage of BDA in the field stated is meant within a speculation – synthesis of new drugs. Therefore characteristic features of BDA are here briefly discussed; they are commonly marked by (five) letters V, coming from the following concepts: Volume, Velocity, Variety, Veracity, Value. In the research performed it was found that BDA unfortunately seems to have rather restricted applicability in planning of chemical compounds; rather we have to focus in details of a single, chosen reaction. Therefore in a second part of the paper – in its core – the Achmatowicz reaction is selected to expose the required ingenuity in organic synthesis. As a pattern for discussion, the structure of Bao Gong Tung A molecule, a novel natural product showing strong antiglaucoma properties, was fixed.
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References
Achmatowicz Jr., O., et al.: Synthesis of methyl 2,3-dideoxy-DL-alk-2-enopyranosides from furan compounds: a general approach to the total synthesis of monosaccharides. Tetrahedron 27(10), 1973–1996 (1971). https://doi.org/10.1016/s0040-4020(01)98229-8
Bøgevig, A., Federsel, H.J., Huerta, F., Hutchings, M.G., Kraut, H., Langer, T., Lőw, P., Oppawsky, C., Rein, T., Saller, H.: Route design in the 21st century - the IC SYNTH software tool as an idea generator for synthesis predictions. Org. Process Res. Dev. 19, 357–368 (2015)
Dunin-Wąsowicz, P.: Polska biblioteka widmowa. Leksykon książek zmyślonych, Narodowe Centrum Kultury, Warszawa (2017). (in Polish)
Grzymała-Busse, J.W., Hippe, Z.S., Mroczek, T.: Eksploracja danych medycznych. Metody sztucznej inteligencji w projektowaniu syntez leków, Wyższa Szkoła Informatyki i Zarządzania - Wydawnictwo IVG, Rzeszów-Szczecin (2015). (in Polish)
Hippe Z.S.: Human interaction in planning chemical syntheses. Some problems of retrosynthesis. In: Hippe Z.S., Kulikowski J.L., Mroczek T. (eds.) Human-Computer Systems Interaction, pp. 67–l 79. Springer, Cham (2018)
http://hyper.com/. Accessed 18 Sept 2017
Japkowicz N., Stefanowski J. (eds.): Big Data Analysis - New Algorithms for a New Society. Studies in Big Data, vol. 16. Springer (2016). https://doi.org/10.1007/978-3-319-26989-4_1
Warren, S., Wayatt, P.: Organic Synthesis. The Disconnection Approach. Wiley, Chichester (2013)
Zhang, Y., Liebeskind, L.S.: Organometallic enantiomeric scaffolding: organometallic chirons. Total synthesis of (-)-Bao Gong Teng A by a molybdenum-mediated [5+2] cycloaddition. J. Am. Chem. Soc. 128(2), 465–472 (2006)
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Hippe, Z.S., Niemiec, R. (2019). New Challenges for Information Technologies in Medicine: Big Data Analysis?. In: Pietka, E., Badura, P., Kawa, J., Wieclawek, W. (eds) Information Technology in Biomedicine. ITIB 2018. Advances in Intelligent Systems and Computing, vol 762. Springer, Cham. https://doi.org/10.1007/978-3-319-91211-0_45
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DOI: https://doi.org/10.1007/978-3-319-91211-0_45
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