Abstract
A formal description is developed for the phenomenon of leukocyte recruitment that plays a critical role in the immune response. Due to its complex nature and capability to rapidly adapt to the attack of infectious agents, the immune system may be considered a typical example of complex adaptive system [9].
Here the leukocyte selective recruitment, crucial in immunity, is modeled as a dynamical system of interactions between leukocytes and endothelial cells, where a special kind of membrane structure turns out to be a very useful tool in the formal analysis of the recruitment process. In our membrane system, besides the traditional rules for communication and transformation of P systems [8], rules are allowed for the expression of receptors, for adhesion between membranes, and for the encapsulation of a membrane inside another membrane.
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References
Bernardini, F., Manca, V.: Dynamical Aspects of P Systems. BioSystems 70(2), 85–93 (2003)
Bernardini, F., Manca, V.: P Systems with Boundary Rules. In: Păun, G., Rozenberg, G., Salomaa, A., Zandron, C. (eds.) WMC 2002. LNCS, vol. 2597, pp. 107–118. Springer, Heidelberg (2002)
D’ambrosio, D., Albanesi, C., Lang, R., Girolomoni, G., Sinigaglia, F., Laudanna, C.: Quantitative Differences in Chemokine Receptor Engagement Generate Diversity in Integrin-Dependent Lymphocyte Adhesion. The Journal of Immunology, 2303–2312
Kitano, H.: Computational Systems Biology. Nature 420, 206–210 (2002)
Kitano, H.: Systems Biology: A Brief Overview. Science 295, 1662–1664 (2002)
Paul, W.E.: Fundamental Immunology, 2nd edn. Raven Press Ltd., New York (1989)
Păun, A., Păun, G.: The Power of Communication: P Systems with Symport/Antiport. New Generation Computing 20(3), 295–306 (2002)
Păun, G.: Membrane Computing. An Introduction. Springer, Berlin (2002)
Segel, L.A., Cohen, I.R.: Design Principles for the Immune System and Other Distributed Autonomous Systems. In: Santa Fe Institute Studies in the Sciences of Complexity. Oxford University Press, Oxford (2001)
Suzuki, Y., Fujiwara, Y., Tanaka, H., Takabayashi, J.: Artificial Life Applications of a Class of P Systems: Abstract Rewriting Systems on Multisets. In: Calude, C.S., Pun, G., Rozenberg, G., Salomaa, A. (eds.) Multiset Processing. LNCS, vol. 2235, pp. 299–346. Springer, Heidelberg (2001)
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Franco, G., Manca, V. (2004). A Membrane System for the Leukocyte Selective Recruitment. In: Martín-Vide, C., Mauri, G., Păun, G., Rozenberg, G., Salomaa, A. (eds) Membrane Computing. WMC 2003. Lecture Notes in Computer Science, vol 2933. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-24619-0_13
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DOI: https://doi.org/10.1007/978-3-540-24619-0_13
Publisher Name: Springer, Berlin, Heidelberg
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