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A Simple Data Analysis Method for Kinetic Parameters Estimation from Renal Measurements with a Three-Headed SPECT System

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Computational Science and Its Applications – ICCSA 2004 (ICCSA 2004)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 3044))

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Abstract

We present here a new method for the determination of renal kinetic parameters from time-activity curves (TACs) obtained in dynamic tomographic Nuclear Medicine studies. The method allows to achieve subsecond sampling rates when using three-headed Single Photon Emission Computed Tomography (SPECT) systems.

We used three-projections data sets in order to directly reconstruct region-of-interest (ROI) contents and to achieve an accurate description of the TACs. By defining a kinetic model for the behavior of the tracer we were able to relate each sampling point of the renal TAC to the correspondent point of the plasmatic TAC (input function).

We analyzed simulated projections in 81 cases of region segmentation errors: the values of the renal clearances were reproduced within about -12% and +4%. The vascular fractions were reproduced within the measurement errors.

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References

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Author information

Authors and Affiliations

  1. Dep. of Phatophysiology, University of Florence, 50134, Florence, Italy

    Eleonora Vanzi & Andreas Robert Formiconi

  2. INFM Genova, 16146, Genova, Italy

    Andreas Robert Formiconi

Authors
  1. Eleonora Vanzi
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  2. Andreas Robert Formiconi
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Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Perugia, Via Elce di Sotto, 8, I-06123, Perugia, Italy

    Antonio Laganá

  2. Department of Computer Science, University of Calgary, 2500 University Drive N.W., T2N 1N4, Calgary AB, Canada

    Marina L. Gavrilova

  3. William Norris Professor, Head of the Computer Science and Engineering Department, University of Minnesota, USA

    Vipin Kumar

  4. School of Computing, Soongsil University, Seoul, Korea

    Youngsong Mun

  5. OptimaNumerics Ltd., Cathedral House, 23-31 Waring Street, BT1 2DX, Belfast, UK

    C. J. Kenneth Tan

  6. Department of Mathematics and Computer Science, University of Perugia, via Vanvitelli, 1, I-06123, Perugia, Italy

    Osvaldo Gervasi

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© 2004 Springer-Verlag Berlin Heidelberg

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Vanzi, E., Formiconi, A.R. (2004). A Simple Data Analysis Method for Kinetic Parameters Estimation from Renal Measurements with a Three-Headed SPECT System. In: Laganá, A., Gavrilova, M.L., Kumar, V., Mun, Y., Tan, C.J.K., Gervasi, O. (eds) Computational Science and Its Applications – ICCSA 2004. ICCSA 2004. Lecture Notes in Computer Science, vol 3044. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-24709-8_53

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  • DOI: https://doi.org/10.1007/978-3-540-24709-8_53

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22056-5

  • Online ISBN: 978-3-540-24709-8

  • eBook Packages: Springer Book Archive

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