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IMGT-Choreography: Processing of Complex Immunogenetics Knowledge

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Computational Methods in Systems Biology (CMSB 2004)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 3082))

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Abstract

IMGT, the international ImMunoGeneTics information system® (http://imgt.cines.fr) is a high quality integrated knowledge resource specialized in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates. IMGT provides a common access to standardized data from genome, proteome, genetics and tridimensional structures. The accuracy and the consistency of IMGT data are based on IMGT-ONTOLOGY, a semantic specification of terms used in immunogenetics and immunoinformatics. IMGTONTOLOGY is formalized using XML schemas (IMGT-ML) for interoperability with other information systems. We are developing Web services to automatically query IMGT databases and tools. This is the first step towards IMGT-Choreography which will trigger and coordinate dynamic interactions between IMGT Web services, to process complex significant biological and clinical requests. IMGT-Choreography will further increase the IMGT leadership in immunogenetics medical research (repertoire analysis in autoimmune diseases, AIDS, leukemias,...), biotechnology related to antibody engineering and therapeutical approaches.

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Authors and Affiliations

  1. Laboratoire d’ImmunoGénétique Moléculaire LIGM, Université Montpellier II, UPR CNRS 1142, Institut de Génétique Humaine IGH, 141 rue de la Cardonille, 34396 Cedex 5, Montpellier, France

    Denys Chaume, Véronique Giudicelli, Kora Combres, Chantal Ginestoux & Marie-Paule Lefranc

  2. Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005, Paris, France

    Marie-Paule Lefranc

Authors
  1. Denys Chaume
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  2. Véronique Giudicelli
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  3. Kora Combres
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  4. Chantal Ginestoux
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  5. Marie-Paule Lefranc
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Editors and Affiliations

  1. CNRS, Université Paris Diderot, France

    Vincent Danos

  2. CNRG Genoscope, 2 rue Gaston Cremieux, 91000, Evry, France

    Vincent Schachter

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Chaume, D., Giudicelli, V., Combres, K., Ginestoux, C., Lefranc, MP. (2005). IMGT-Choreography: Processing of Complex Immunogenetics Knowledge. In: Danos, V., Schachter, V. (eds) Computational Methods in Systems Biology. CMSB 2004. Lecture Notes in Computer Science(), vol 3082. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-25974-9_7

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  • DOI: https://doi.org/10.1007/978-3-540-25974-9_7

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  • Print ISBN: 978-3-540-25375-4

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