Skip to main content

Level Set and Region Based Surface Propagation for Diffusion Tensor MRI Segmentation

  • Conference paper
Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis (MMBIA 2004, CVAMIA 2004)

Abstract

Diffusion Tensor Imaging (DTI) is a relatively new modality for human brain imaging. During the last years, this modality has become widely used in medical studies. Tractography is currently the favorite technique to characterize and analyse the structure of the brain white matter. Only a few studies have been proposed to group data of particular interest. Rather than working on extracted fibers or on an estimated scalar value accounting for anisotropy as done in other approaches, we propose to extend classical segmentation techniques based on surface evolution by considering region statistics defined on the full diffusion tensor field itself. A multivariate Gaussian is used to approximate the density of the components of diffusion tensor for each sub-region of the volume. We validate our approach on synthetical data and we show promising results on the extraction of the corpus callosum from a real dataset.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albers, G.W., Lansberg, M.G., Norbash, A.M., Tong, D.C., Oā€™Brien, M.W., Woolfenden, A.R., Marks, M.P., Moseley, M.E.: Yield of diffusion-weighted MRI for detection of potentially relevant findings in stroke patients. NeurologyĀ 54, 1562ā€“1567 (2000)

    Google ScholarĀ 

  2. Baird, A.E., Warach, S.: Magnetic resonance imaging of acute stroke. J. Cerebral Blood Flow MetabolismĀ 18, 582ā€“609 (1998)

    Google ScholarĀ 

  3. Basser, P.J., Mattiello, J., LeBihan, D.: Estimation of the effective self-diffusion tensor from the NMR spin echo. Journal of Magnetic ResonanceĀ B(103), 247ā€“254 (1994)

    Google ScholarĀ 

  4. Basser, P.J., Mattiello, J., LeBihan, D.: MR diffusion tensor spectroscopy and imaging. BiophysicaĀ 66, 259ā€“267 (1994)

    ArticleĀ  Google ScholarĀ 

  5. Basser, P.J., Pajevic, S., Pierpaoli, C., Duda, J., Aldroubi, A.: In vivo fiber tractography using DT-MRI data. Magn. Res. Med.Ā 44, 625ā€“632 (2000)

    ArticleĀ  Google ScholarĀ 

  6. Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., Laval- Jeantet, M.: MR imaging of intravoxel incoherent motions: Application to diffusion and perfusion in neurologic disorders. Radiology, 401ā€“407 (1986)

    Google ScholarĀ 

  7. Bjornemo, M., Brun, A., Kikinis, R., Westin, C.F.: Regularized stochastic white matter tractography using diffusion tensor MRI. In: MICCAI, pp. 435ā€“442 (2002)

    Google ScholarĀ 

  8. Campbell, J.S.W., Siddiqi, K., Vemuri, B.C., Pike, G.B.: A geometric flow for white matter fibre tract reconstruction. In: IEEE International Symposium on Biomedical Imaging Conference Proceedings, July 2002, pp. 505ā€“508 (2002)

    Google ScholarĀ 

  9. Chan, T., Vese, L.: An active contour model without edges. In: Nielsen, M., Johansen, P., Fogh Olsen, O., Weickert, J. (eds.) Scale-Space 1999. LNCS, vol.Ā 1682, pp. 141ā€“151. Springer, Heidelberg (1999)

    ChapterĀ  Google ScholarĀ 

  10. Cicarelli, O., Toosy, A.T., Parker, G.J.M., Wheeler-Kingshott, C.A.M., Barker, G.J., Miller, D.H., Thompson, A.J.: Diffusion tractography based group mapping of major white matter pathways in the human brain. NeuroImageĀ 19, 1545ā€“1555 (2003)

    ArticleĀ  Google ScholarĀ 

  11. Ding, Z., Gore, J.C., Anderson, A.W.: Classification and quantification of neuronal fiber pathways using diffusion tensor MRI. Magn. Res. Med.Ā 49, 716ā€“721 (2003)

    ArticleĀ  Google ScholarĀ 

  12. Feddern, C., Weickert, J., Burgeth, B.: Level-set methods for tensor-valued images. In: Proc. Second IEEE Workshop on Variational, Geometric and Level Set Methods in Computer Vision, Nice, France, pp. 65ā€“72 (2003)

    Google ScholarĀ 

  13. Hagmann, P., Thiran, J.P., Jonasson, L., Vandergheynst, P., Clarke, S., Maeder, P., Meuli, R.: DTI mapping of human brain connectivity: Statistical fiber tracking and virtual dissection. NeuroImageĀ 19, 545ā€“554 (2003)

    ArticleĀ  Google ScholarĀ 

  14. Lazar, M., Weinstein, D., Hasan, K., Alexander, A.L.: Axon tractography with tensorlines. In: Proceedings of International Society of Magnetic Resonance in Medicine, vol.Ā 482 (2000)

    Google ScholarĀ 

  15. Lazar, M., Weinstein, D.M., Tsuruda, J.S., Hasan, K.M., Arfanakis, K., Meyerand, M.E., Badie, B., Rowley, H.A., Haughton, V., Field, A., Alexander, A.L.: White matter tractography using diffusion tensor deflection. Human Brain MappingĀ 18, 306ā€“321 (2003)

    ArticleĀ  Google ScholarĀ 

  16. Lenglet, C., Deriche, R., Faugeras, O.: Inferring white matter geometry from diffusion tensor MRI: Application to connectivity mapping. In: Pajdla, T., Matas, J. (eds.) Proceedings of the 8th European Conference on Computer Vision, Prague, Czech Republic, May 2004, Springer, Heidelberg (2004)

    Google ScholarĀ 

  17. McGraw, T.E.:Neuronal fiber tracking in DT-MRI. Masterā€™s thesis, University of Florida (2002)

    Google ScholarĀ 

  18. Merboldt, K.D., Hanicke, W., Frahm, J.: Self-diffusion NMR imaging using stimulated echoes. J. Magn. Reson.Ā 64, 479ā€“486 (1985)

    Google ScholarĀ 

  19. Mori, S., Crain, B.J., Chacko, V.P., Van Zijl, P.C.M.: Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of NeurologyĀ 45(2), 265ā€“269 (1999)

    ArticleĀ  Google ScholarĀ 

  20. Mori, S., Crain, B.J., van Zijl, P.C.: 3d brain fiber reconstruction from diffusion MRI. In: Proceedings of the International Conference on Functional Mapping of the Human Brain (1998)

    Google ScholarĀ 

  21. Moseley, M.E., Cohen, Y., Kucharczyk, J., Mintorovitch, J., Asgari, H.S., Wendland, M.F., Tsuruda, J., Norman, D.: Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. RadiologyĀ 176, 439ā€“445 (1999)

    Google ScholarĀ 

  22. Moseley, M.E., Cohen, Y., Mintorovitch, J., Kucharczyk, J., Tsuruda, J., Weinstein, P., Norman, D.: Evidence of anisotropic self-diffusion. RadiologyĀ 176, 439ā€“445 (1990)

    Google ScholarĀ 

  23. Oā€™Donnell, L., Haker, S., Westin, C.F.: New approaches to estimation of white matter connectivity in diffusion tensor MRI: Elliptic pdes and geodesics in a tensorwarped space. In: MICCAI, pp. 459ā€“466 (2002)

    Google ScholarĀ 

  24. Paragios, N., Deriche, R.: Geodesic active regions and level set methods for supervised texture segmentation. The International Journal of Computer VisionĀ 46(3), 223 (2002)

    ArticleĀ  MATHĀ  Google ScholarĀ 

  25. Parker, G.J.M.: Tracing fibers tracts using fast marching. In: Proceedings of the International Society of Magnetic Resonance, vol.Ā  85 (2000)

    Google ScholarĀ 

  26. Parker, G.J.M., Alexander, D.C.: Probabilistic monte carlo based mapping of cerebral connections utilising whole-brain crossing fibre information. In: IPMI, pp. 684ā€“695 (2003)

    Google ScholarĀ 

  27. Parker, G.J.M., Wheeler-Kingshott, C.A.M., Barker, G.J.: Estimating distributed anatomical connectivity using fast marching methods and diffusion tensor imaging. Trans. Med. ImagingĀ 21(5), 505ā€“512 (2002)

    ArticleĀ  Google ScholarĀ 

  28. Poupon, C.: Dtection des faisceaux de fibres de la substance blanche pour lā€™tude de la connectivit anatomique crbrale. PhD thesis, Ecole Nationale Suprieure des Tlcommunications (December 1999)

    Google ScholarĀ 

  29. Rousson, M., Deriche, R.: A variational framework for active and adaptative segmentation of vector valued images. In: Proc. IEEE Workshop on Motion and Video Computing, Orlando, Florida, December 2002, pp. 56ā€“62 (2002)

    Google ScholarĀ 

  30. Rousson, M., Brox, T., Deriche, R.: Active unsupervised texture segmentation on a diffusion based space. In: IEEE Conference on Computer Vision and Pattern Recognition, Madison,Wisconsin, USA, June 2003, vol.Ā 2, pp. 699ā€“704 (2003)

    Google ScholarĀ 

  31. Sotak, C.: The role of diffusion tensor imaging (DTI) in the evaluation of ischemic brain injury. NMR Biomed.Ā 15, 561ā€“569 (2002)

    ArticleĀ  Google ScholarĀ 

  32. Stejskal, E.O., Tanner, J.E.: Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. Journal of Chemical PhysicsĀ 42, 288ā€“292 (1965)

    ArticleĀ  Google ScholarĀ 

  33. Talos, I.-F., Oā€™Donnell, L., Westin, C.-F., Warfield, S., Wells III, W., Yoo, S.-S., Panych, L., Golby, A., Mamata, H., Maier, S., Ratiu, P., Guttmann, C., Black, P., Jolesz, F., Kikinis, R.: Diffusion tensor and functional MRI fusion with anatomical MRI for image-guided neurosurgery. In: MICCAI, pp. 407ā€“415 (2003)

    Google ScholarĀ 

  34. Tschumperl, D., Deriche, R.: Variational frameworks for DT-MRI estimation, regularization and visualization. In: Proceedings of the 9th International Conference on Computer Vision, Nice, France, IEEE Computer Society, Los Alamitos (2003)

    Google ScholarĀ 

  35. Tuch, D.S.: Mapping cortical connectivity with diffusion MRI. In: ISBI, pp. 392ā€“394 (2002)

    Google ScholarĀ 

  36. Tuch, D.S., Reese, T.G., Wiegell, M.R., Makris, N.G., Belliveau, J.W., Wedeen, V.J.: High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magn. Res. Med.Ā 48, 577ā€“582 (2002)

    ArticleĀ  Google ScholarĀ 

  37. Vemuri, B., Chen, Y., Rao, M., McGraw, T., Mareci, T., Wang, Z.: Fiber tract mapping from diffusion tensor MRI. In: 1st IEEE Workshop on Variational and Level Set Methods in Computer Vision, VLSM 2001 (July 2001)

    Google ScholarĀ 

  38. Wang, Z., Vemuri, B.C.: Tensor field segmentation using region based active contour model. In: Proc. The 8th European Conference on Computer Vision, Prague, Czech Republic (May 2004)

    Google ScholarĀ 

  39. Weinstein, D.M., Kindlmann, G.L., Lundberg, E.C.: Tensorlines: Advectiondiffusion based propagation through tensor fields. IEEE Visualization, 249ā€“253 (1999)

    Google ScholarĀ 

  40. Westin, C.F., Maier, S.E., Mamata, H., Nabavi, A., Jolesz, F.A., Kikinis, R.: Processing and visualization for diffusion tensor MRI. In: Proceedings of Medical Image AnalysisĀ 6(2), 93ā€“108 (2002)

    ArticleĀ  Google ScholarĀ 

  41. Wiegell, M.R., Tuch, D.S., Larson, H.W.B., Wedeen, V.J.: Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging. NeuroImageĀ 19, 391ā€“402 (2003)

    ArticleĀ  Google ScholarĀ 

  42. Zhukov, L., Barr, A.H.: Oriented tensor reconstruction: Tracing neural pathways from diffusion tensor MRI. In: Proceedings of the conference on Visualization 2002, pp. 387ā€“394 (2002)

    Google ScholarĀ 

  43. Zhukov, L., Museth, K., Breen, D., Whitaker, R., Barr, A.H.: Level set segmentation and modeling of DT-MRI human brain data. Journal of Electronic Imaging (2003)

    Google ScholarĀ 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

Ā© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Rousson, M., Lenglet, C., Deriche, R. (2004). Level Set and Region Based Surface Propagation for Diffusion Tensor MRI Segmentation. In: Sonka, M., Kakadiaris, I.A., Kybic, J. (eds) Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis. MMBIA CVAMIA 2004 2004. Lecture Notes in Computer Science, vol 3117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-27816-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-27816-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22675-8

  • Online ISBN: 978-3-540-27816-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics