Abstract
We propose the use of a continuity heuristic for solving the inclination ambiguity of polarized light imaging, which is a high resolution method of mapping the spatially varying pattern of anisotropy in biological and non-biological samples. Applied to the white matter of the brain, solving the inclination ambiguity of polarized light imaging will allow the creation of a 3D model of fibers. We use the continuity heuristic in several methods, some of which employ the simulated annealing algorithm to reinforce the heuristic, while others proceed deterministically to solve the inclination ambiguity. We conclude by explaining the limitations of the continuity heuristic approach.
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References
Axer, H., Lippitz, B., Keyserlingk, D.: Morphological asymmetry in anterior limb of human internal capsule revealed by confocal laser and polarized light microscopy. Psychiatry Res. Neuroimaging 91, 141–154 (1999)
Axer, H., Berks, G., Keyserlingk, D.: Visualization of nerve fibre orientation in gross histo-logical sections of the human brain. Microscopy Res. and Technique 51(5), 481–492 (2000)
Axer, H., Keyserlingk, D.: Mapping of fibre orientation in human internal capsule by means of polarized light and confocal scanning laser microscopy. J. Neuroscience Methods 94, 165–175 (2000)
Axer, H., Axer, M., Krings, T., Keyserlingk, D.G.V.: Quantitative estimation of 3-D fibre course in gross histological sections of the human brain using polarized light. Journal of Neuroscience Methods 105, 121–131 (2001)
Axer, H., Leunert, M., Mürköster, M., Gräßel, D., Larsen, L., Griffin, L.D., Keyserlingk, G.: Keyserlingk D A 3D fibre model of the human brainstem. Comp. Med. Imag. & Graphics 26, 439–444 (2002)
Basser, P.J., Mattiello, J., Le Bihan, D., et al.: Estimation of the effective self-diffusion tensor from the NMR spin echo. J. Magn. Res., Series B 103, 259–267 (1994)
Bucci, M.: Optimization with Simulated Annealing. C/C++ Users Journal 19(11), 10–27 (2001)
Coremans, J., Luypaert, R., Verhelle, F., Stadnik, T., Osteaux, M.: A method for myelin fibre orientation mapping using diffusion-weighted MR images. Mag. Reson. Imag. 12(3), 443–454 (1994)
Fraher, J., Macconai, M.: Fibre bundles in the CNS revealed by polarized light. J. Anat. 106, 170 (1970)
Geday, M.A.: Birefringence Imaging Jesus College Oxford (2001)
Jones, D.K., Simmons, A., Williams, S.C.R., Horsfield, M.A.: Non-invasive assessment of axonal fibre connectivity in the human brain via diffusion tensor MRI. Magnetic Resonance in Medicine 42, 37–41 (1999)
Kilossy, J., van der Loos, H.: Cholestrol ester crystals in polarised light show pathways in the human brain. Brain Res. 426, 377–380 (1987)
Kretschmann, H.J.: On the demonstration of myelinated nerve fibres by polarized light without extinction effects. J. Hirnforsch 9, 571–575 (1967)
Le Bihan, D., Breton, E., Lallemand, D., et al.: MR imaging of intravoxel incoherent mo-tions: application to diffusion and perfusion in neurologic disorders. Radiology 161, 401–407 (1986)
Le Bihan, D., Turner, R., Douek, P.: Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study. NeuroReport 4, 887–890 (1993)
Napadow, V.J., Wedeen, V., Chen, Q., et al.: Quantification of Fibre Orientation with Diffusion Tensor MR Imaging and 3D Resolved Two-Photon Microscopy. Paper presented at the ISMRM, Denver (2000)
Norris, D.G.: The effects of microscopic tissue parameters on the diffusion weighted magnetic resonance imaging experiment. Nmr. in Biomedicine 14, 77–93 (2001)
Oxford Cryosystems, http://www.metripol.com/
Pierpaoli, C., Basser, P.J.: Toward a quantitative assessment of diffusion anisotropy. Magn. Reson. Med. 36(6), 893–906 (1996)
Sadun, A.A., Schaechter, J.D.: Tracing axons in the human brain; a method utilizing light and TEM techniques. J. Electron Microsc. Techn. 2, 175–186 (1985)
Thomsen, C., Henriksen, O., Ring, P.: e In vivo measurement of water self-diffusion in the human brain by magnetic resonance imaging. Acta Radiologica 28(3), 353–361 (1987)
Vidal, C.B., Mello, M.L.S., Caseirofilho, A.C.: GODO C Anisotropic properties of the myelin sheath. Acta Histochemica 66(1), 32–39 (1980)
Whitaker, S.: Diffusion and dispersion in porous media. AIChE Journal 13, 420 (1967)
Zhang, J., Zijl, P.C.M., Mori, S.: Three-dimensional diffusion tensor microimaging of the adult mouse brain and hippocampus. Neuroimage 15, 892–901 (2002)
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Larsen, L., Griffin, L.D. (2004). Can a Continuity Heuristic Be Used to Resolve the Inclination Ambiguity of Polarized Light Imaging?. In: Sonka, M., Kakadiaris, I.A., Kybic, J. (eds) Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis. MMBIA CVAMIA 2004 2004. Lecture Notes in Computer Science, vol 3117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-27816-0_31
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DOI: https://doi.org/10.1007/978-3-540-27816-0_31
Publisher Name: Springer, Berlin, Heidelberg
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