Skip to main content

RgS-Miner: A Biological Data Warehousing, Analyzing and Mining System for Identifying Transcriptional Regulatory Sites in Human Genome

  • Conference paper
Database and Expert Systems Applications (DEXA 2004)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 3180))

Included in the following conference series:

  • 670 Accesses

Abstract

Recently, biological databases and analytical methods have become available for analyzing gene expression and transcriptional regulatory sequences. However, users must make the complicated analyses to query the data in various databases, and then they must analyze the gene upstreams using various predictive tools, before finally converting date among formats. Beyond methods for predicting transcriptional regulatory sites, new automated and integrated methods for analyzing gene upstream sequences on a higher level are urgently required. Efficient and integrated data management methods are essential, too. We present an integrated system, namely RgS-Miner, to predict transcriptional regulatory sites and detect co-occurrence of these regulatory sites. RgS-Miner comprises a biological data warehousing system, patte rn discovery programs, pattern occurrence association detectors and user interfaces. The system is available at http://rgsminer.csie.ncu.edu.tw/.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pruitt, K.D., Maglott, D.R.: RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res. 29(1), 137–140 (2001)

    Article  Google Scholar 

  2. Hubbard, T., et al.: The Ensembl genome database project. Nucleic Acids Res. 30(1), 38–41 (2002)

    Article  MathSciNet  Google Scholar 

  3. Wingender, E., et al.: The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 29(1), 281–283 (2001)

    Article  Google Scholar 

  4. Ohler, U., Niemann, H.: Identification and analysis of eukaryotic promoters: recent computational approaches. Trends Genet 17(2), 56–60 (2001)

    Article  Google Scholar 

  5. Benson, G.: Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res. 27(2), 573–580 (1999)

    Article  MathSciNet  Google Scholar 

  6. Van Helden, J., et al.: A web site for the computational analysis of yeast regulatory sequences. Yeast 16(2), 177–187 (2000)

    Article  Google Scholar 

  7. Lawrence, C.E., et al.: Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment. Science 262(5131), 208–214 (1993)

    Article  Google Scholar 

  8. Bailey, T.L., Elkan, C.: Fitting a mixture model by expectation maximization to discover motifs in biopolymers. In: Proc Int Conf. Intell. Syst. Mol. Biol., vol. 2, pp. 28–36 (1994)

    Google Scholar 

  9. Hughes, J.D., et al.: Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae. J. Mol. Biol. 296(5), 1205–1214 (2000)

    Article  Google Scholar 

  10. Horng, J.T., et al.: Mining putative regulatory elements in promoter regions of Saccharomyces cerevisiae. Silico. Biol. 2(3), 263–273 (2002)

    Google Scholar 

  11. Horng, J.T., et al.: The repetitive sequence database and mining putative regulatory elements in gene promoter regions. J. Comput. Biol. 9(4), 621–640 (2002)

    Article  Google Scholar 

  12. Srikant, R., et al.: Mining Generalized Association Rules, pp. 407–419 (1995)

    Google Scholar 

  13. Jensen, L.J., Knudsen, S.: Automatic discovery of regulatory patterns in promoter regions based on whole cell expression data and functional annotation. Bioinformatics 16(4), 326–333 (2000)

    Article  Google Scholar 

  14. Sudarsanam, P., et al.: Genome-wide co-occurrence of promoter elements reveals a cisregulatory cassette of rRNA transcription motifs in Saccharomyces cerevisiae. Genome Res. 12(11), 1723–1731 (2002)

    Article  Google Scholar 

  15. Van Helden, J., et al.: Extracting regulatory sites from the upstream region of yeast genes by computational analysis of oligonucleotide frequencies. J. Mol. Biol. 281(5), 827–842 (1998)

    Article  Google Scholar 

  16. Hertz, G.Z., Stormo, G.D.: Identifying DNA and protein patterns with statistically significant alignments of multiple sequences. Bioinformatics 15(7-8), 563–577 (1999)

    Article  Google Scholar 

  17. Workman, C.T., Stormo, G.D.: ANN-Spec: a method for discovering transcription factor binding sites with improved specificity. In: Pac Symp Biocomput, pp. 467–478 (2000)

    Google Scholar 

  18. Brazma, A., et al.: Data mining for regulatory elements in yeast genome. In: Proc Int Conf. Intell. Syst. Mol. Biol., vol. 5, pp. 65–74 (1997)

    Google Scholar 

  19. Aerts, S., et al.: Toucan: deciphering the cis-regulatory logic of coregulated genes. Nucleic Acids Res. 31(6), 1753–1764 (2003)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sun, YM., Huang, HD., Horng, JT., Huang, SL., Tsou, AP. (2004). RgS-Miner: A Biological Data Warehousing, Analyzing and Mining System for Identifying Transcriptional Regulatory Sites in Human Genome. In: Galindo, F., Takizawa, M., Traunmüller, R. (eds) Database and Expert Systems Applications. DEXA 2004. Lecture Notes in Computer Science, vol 3180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30075-5_72

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-30075-5_72

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-22936-0

  • Online ISBN: 978-3-540-30075-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics