Abstract
Abnormal neuro-development and brain structure may play a role in the pathophysiology of schizophrenia. To study morphology and age-related changes in this disease, we started with a set of cranial MRI’s of 46 schizophrenia patients and age/gender matched healthy controls. First, we deformed a template brain image to our set of subject images. The Jacobian fields of these deformations were then reduced to sets of 52 normalized region volumes for each subject using a neuro-anatomical atlas. The normalized regional volumes of the control and patient groups were compared using Student’s t-test. In addition, the age correlation of each region volume was calculated for the two groups. All results were corrected for multiple comparisons using permutation testing. Finally, we used a classifier based on support vector machines and a feature selection method in order to determine our ability to discriminate brains of controls from those of patients. RESULTS: Analysis of the region-integrated Jacobians showed an enlargement of the third ventricle in patients. The age-correlation study demonstrated significant positive correlation in the third ventricle and right thalamus of controls, but not patients. Using an average of 6.5 features, our classifier was able to correctly identify 72% of patients and 70% of controls. CONCLUSIONS: In addition to enlargement of the third ventricle, the brains of schizophrenia patients demonstrate a different pattern of age-related changes.
Chapter PDF
Similar content being viewed by others
Keywords
- Schizophrenia Patient
- Feature Selection Method
- Registration Method
- Middle Temporal Gyrus
- Superior Parietal Lobule
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Gur, R.E., Cowell, P.E., Latshaw, A., Turetsky, B.I., Grossman, R.I., Arnold, S.E., Bilker, W.B., Gur, R.C.: Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Arch. Gen. Psychiatry 57(8), 761–768 (2000)
Gur, R.E., Turetsky, B.I., Cowell, P.E., Finkelman, C., Maany, V., Grossman, R.I., Arnold, S.E., Bilker, W.B., Gur, R.C.: Temporolimbic volume reductions in schizophrenia. Arch. Gen. Psychiatry 57(8), 769–775 (2000)
Cahn, W., Pol, H.E., Bongers, M., Schnack, H.G., Mandl, R.C., Van Haren, N.E., Durston, S., Koning, H., Van Der Linden, J.A., Kahn, R.S.: Brain morphology in antipsychotic-naive schizophrenia: A study of multiple brain structures. Br. J. Psychiatry – Suppl. 43, s66–72 (2002)
Gur, R.E., Maany, V., Mozley, D., Swanson, C., Bilker, W., Gur, R.C.: Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am. J. Psychiatry 155, 1711–1717 (1998)
Keshavan, M.S., Rosenberg, D., Sweeney, J.A., Pettegrew, J.W.: Decreased caudate volume in neuroleptic-naive psychotic patients. Am. J. Psychiatry 155(6), 774–778 (1998)
Delisi, L.E.: Regional brain volume change over the life-time course of schizophrenia. J. Psychiatr. Res. 33, 535–541 (1999)
Woods, B.T., Yurgelun-Todd, D., Benes, F.M., Frankenburg, F.R., Pope Jr., H.G., McSparren, J.: Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course. Biol. Psychiatry 27(3), 341–352 (1990)
Rapoport, J.L., Giedd, J., Kumra, S., Jacobsen, L., Smith, A., Lee, P., Nelson, J., Hamburger, S.: Childhood-onset schizophrenia progressive ventricular change during adolescence. Arch. Gen. Psychiatry 54(10), 897–903 (1997)
Shtasel, D.L., Gur, R.E., Mozley, P.D., Richards, J., Taleff, M.M., Heimberg, C., Gallacher, F., Gur, R.C.: Volunteers for biomedical research: recruitment and screening of normal controls. Arch. Gen. Psychiatry 48, 1022–1025 (1991)
Gur, R.C., Turetsky, B.I., Matsui, M., Yan, M., Bilker, W., Hughett, P., Gur, R.E.: Sex differences in brain gray and white matter in healthy young adults. J. Neurosci. 19, 4065–4072 (1999)
Shattuck, D.W., Sandor-Leahy, S.R., Schaper, K.A., Rottenberg, D.A., Leahy, R.M.: Magnetic resonance image tissue classification using a partial volume model. Neuroimage 13(5), 856–876 (2001)
Kwan, R.K.-S., Evans, A.C., Pike, G.B.: An extensible MRI simulator for post-processing evaluation. In: Höhne, K.H., Kikinis, R. (eds.) VBC 1996. LNCS, vol. 1131, pp. 135–140. Springer, Heidelberg (1996)
Collins, D.L., Zijdenbos, A.P., Kollokian, V., Sled, J.G., Kabani, N.J., Holmes, C.J., Evans, A.C.: Design and construction of a realistic digital brain phantom. IEEE Transactions on Medical Imaging 17, 463–468 (1998)
Thirion, J.P.: Image matching as a diffusion process: an analogy with Maxwell’s demons. Med. Image Anal. 2(3), 243–260 (1998)
Nichols, T.E., Holmes, A.P.: Nonparametric analysis of pet functional neuroimaging experiments: A primer. Human Brain Mapping 15, 1–25 (2001)
Bradley, P.S., Mangasarian, O.L., Street, W.N.: Feature selection via mathematical programming. INFORMS Journal on Computing 10, 209–217 (1998)
McCarley, R., Wible, C., Frumin, M., Hirayasu, Y., Levitt, J., Fischer, I., Shenton, M.: Mri anatomy of schizophrenia. Biol. Psychiatry 45, 1099–1119 (1999)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dubb, A., Yushkevich, P., Xie, Z., Gur, R., Gur, R., Gee, J. (2004). Regional Structural Characterization of the Brain of Schizophrenia Patients. In: Barillot, C., Haynor, D.R., Hellier, P. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2004. MICCAI 2004. Lecture Notes in Computer Science, vol 3217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30136-3_84
Download citation
DOI: https://doi.org/10.1007/978-3-540-30136-3_84
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22977-3
Online ISBN: 978-3-540-30136-3
eBook Packages: Springer Book Archive