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Influence of Dendritic Spine Morphology on Spatiotemporal Change of Calcium/Calmoduline-Dependent Protein Kinase Density

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Neural Information Processing (ICONIP 2004)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 3316))

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Abstract

Glutamic acid sensitivity of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor at spine is an important factor that determines excitatory synaptic weight. It has been suggested that the weight is determined by spine morphology. It was also reported that the thick spines (mushroom type) whose head is fully developed remain mostly stable. Therefore, the memory in the cerebral neuronal circuit is possibly stored in the spine morphology. However, it is still unclear how glutamic acid sensitivity varies with the change in spine morphology. In this paper, we show the relation between the spine morphology and the glutamic acid sensitivity. We classify the spines into 3 types (mushroom, thin and stubby) according to physiological observation. We analyze the spatiotemporal dynamics of CaMKII-CaMCa4 concentration, that increases the glutamic acid sensitivity, when calcium ions are injected at the spine head. We find that CaMKII-CaMCa4 concentration in the mushroom-type spine is much higher than those in the others and that its decay is much slower. This result is the first finding that shows the relation between the change in the spine morphology and the glutamic acid sensitivity, which connects synaptic characteristics that determines the brain functions and the spine morphology.

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Author information

Authors and Affiliations

  1. Department of Frontier Informatics, Graduate School of Frontier Sciences, The University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo, 113–8656, Japan

    Shuichi Kato, Seiichi Sakatani & Akira Hirose

  2. Japan Society for the Promotion of Science,  

    Seiichi Sakatani

Authors
  1. Shuichi Kato
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  2. Seiichi Sakatani
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  3. Akira Hirose
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Editor information

Editors and Affiliations

  1. Indian Statistical Institute, Electronics and Communication Sciences Unit, Kolkata, India

    Nikhil Ranjan Pal

  2. School of Computer and Information Sciences, Knowledge Engineering and Discovery Research Institute (KEDRI), Auckland University of Technology, Private Bag 92006, Auckland, New Zealand

    Nik Kasabov

  3. Department of Instrumentation and Electronics Engineering, Jadavpur University, Salt-lake Campus, 700098, Calcutta, India

    Rajani K. Mudi

  4. Indian Statistical Institute, 203 B. T. Road, 700 108, Calcutta,  

    Srimanta Pal

  5. Indian Statistical Institute, Computer Vision and Pattern Recognition Unit, 700108, Kolkata, India

    Swapan Kumar Parui

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© 2004 Springer-Verlag Berlin Heidelberg

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Kato, S., Sakatani, S., Hirose, A. (2004). Influence of Dendritic Spine Morphology on Spatiotemporal Change of Calcium/Calmoduline-Dependent Protein Kinase Density. In: Pal, N.R., Kasabov, N., Mudi, R.K., Pal, S., Parui, S.K. (eds) Neural Information Processing. ICONIP 2004. Lecture Notes in Computer Science, vol 3316. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30499-9_4

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  • DOI: https://doi.org/10.1007/978-3-540-30499-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23931-4

  • Online ISBN: 978-3-540-30499-9

  • eBook Packages: Springer Book Archive

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