Abstract
We present results of morphometric analysis of the lateral ventricles of a group of schizophrenic and control subjects to investigate possible shape differences associated with schizophrenia. Our results show shape changes localised to three regions : the temporal horn (its tip near the amygdala, and along its body near the parahippocampal fissure), the central part of the lateral ventricles around the corpus callosum, and the tip of the anterior horn in the region of the frontal lobe. The differences in the temporal and anterior horns are in regions close to structures thought to be implicated in schizophrenia. The changes observed are the most significant changes (p < 10− 13) in shape parameters calculated using a 3D statistical shape descriptor (point distribution model). Corresponding points on the surface of the ventricles in the training set were obtained using an transportation-based method to match high curvature points.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Babalola, K.O., Graham, J., Kopala, L., Vandorpe, R.: Using the Transportation Algorithm to Improve Point Correspondences in the Construction of 3D PDMs. In: Proc. 6th Annual Conference on Medical Image Understanding and Analysis, Portsmouth, UK, pp. 141–144 (2002)
Buckley, P.F., Dean, D., Bookstein, F.L., Friedman, L., Kwon, D., Lewin, J.S., Kamath, J., Lys, C.: 3D Magnetic Resonance-Based Morphometrics and Ventricular Dysmorphology in Schizophrenia, Biol. Psychiatry 45, 62–67 (1999)
Cootes, T.F., Hill, A., Taylor, C.J., Haslam, J.: The Use of Active Shape Models for Locating Structures in Medical Images. Image and Vision Computing 12(6), 355–366 (1994)
Davies, R.H., Twining, C.J., Cootes, T.F., Waterton, J.C., Taylor, C.J.: 3D Statistical Shape Models Using Direct Optimisation of Description Length. In: Heyden, A., Sparr, G., Nielsen, M., Johansen, P. (eds.) ECCV 2002. LNCS, vol. 2350(3), pp. 3–20. Springer, Heidelberg (2002)
Gerig, G., Styner, M., Jones, D., Weinberger, D., Lieberman, J.: Shape Analysis of Brain Ventricles Using SPHARM. In: Proc. IEEE Workshop on Mathematical Methods in Biomedical Image Analysis, pp. 171–178 (2001)
Hand, D.J.: Discrimination and Classification, vol. ch. 4. John Wiley & Sons, Chichester (1981)
Johnstone, E.C., Crow, T.J., Frith, C.D., Husband, J., Kreel, L.: Cerebral Ventricular Size and Cognitive Impairment in Chronic Schizophrenia. Lancet 7992(2), 924–926 (1976)
Achatz, H., Kleinschmidt, P., Paparizos, K.: A dual forest algorithm for the assignment problem. In: Gritzmann, P., Sturmfels, B. (eds.) DIMACS Series in Discrete Mathematics and Theoretical Computer Science, vol. 4, pp. 1–11 (1991)
Monga, O., Deriche, R., Malandain, G., Cocquerez, J.-P.: Recursive filtering and edge tracking: two primary tools for 3D edge detection. Image and Vision Computing 9(4), 203–214 (1991)
McCarley, R.W., Wible, C.G., Frumin, M., Hirayasu, Y., Levitt, J.J., Fischer, I.A., Shenton, M.E.: MRI Anatomy of Schizophrenia. Biol. Psychiatry 45, 1099–1119 (1999)
Narr, K.L., Thompson, P.M., Sharma, T., Moussai, J., Blanton, R., Anvar, B., Edris, A., Krupp, R., Rayman, J., Khaledy, M., Toga, A.W.: Three-Dimensional Mapping of Tempro-Limbic Regions and the Lateral Ventricles in Schizophrenia: Gender Effects. Biol. Psychiatry 50, 84–97 (2001)
Smith, S.: Fast robust automated brain extraction. Human Brain Mapping 17(3), 143–155 (2002)
Subsol, G., Thirion, J.P., Ayache, N.: A Scheme for Automatically Building Three- Dimensional Morphometric Anatomical Atlases: Application to a Skull Atlas. Medical Image Analysis 2(1), 37–60 (1998)
Thirion, J.P., Gourdon, A.: The 3D Marching Lines Algorithm and its Application to Crest Lines Extraction. Graphical Models and Image Processing 86(6), 503–509 (1996)
Vokurka, E.A., Thacker, N.A., Jackson, A.: A Fast Model-Independent Method for Automatic Correction of Intensity Nonuniformity in MRI Data. JMRI 10(4), 550–562 (1999)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Babalola, K., Graham, J., Honer, W., Kopala, L., Lang, D., Vandorpe, R. (2003). An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects. In: Ellis, R.E., Peters, T.M. (eds) Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003. MICCAI 2003. Lecture Notes in Computer Science, vol 2879. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-39903-2_64
Download citation
DOI: https://doi.org/10.1007/978-3-540-39903-2_64
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20464-0
Online ISBN: 978-3-540-39903-2
eBook Packages: Springer Book Archive