Skip to main content

A Paratope Is Not an Epitope: Implications for Immune Network Models and Clonal Selection

  • Conference paper
Artificial Immune Systems (ICARIS 2003)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2787))

Included in the following conference series:

Abstract

Artificial Immune Systems (AIS) research into clonal selection and immune network models has tended to use a single, real-valued or binary vector to represent both the paratope and epitope of a B-cell; in this paper, the use of alternative representations is discussed. A theoretical generic immune network (GIN) is presented, that can be used to explore the network dynamics of several families of different B-cell representations at the same time, and that combines features of clonal selection and immune networks in a single model.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bersini, H., Calenbuhr, V.: Frustrated chaos in biological networks. J. Theor. Biol. 188, 187–200 (1997)

    Article  Google Scholar 

  • Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge (1959)

    Google Scholar 

  • De Boer, R.J., Kevrekidis, I.G., Perelson, A.S.: Immune network behavior II: From oscillations to chaos and stationary states. Only the long abstract could be obtained for this paper (1992)

    Google Scholar 

  • de Castro, L.N., Von Zuben, F.J.: The clonal selection algorithm with engineering applications. In: Proceedings of GECCO 2000, Workshop on Artificial Immune Systems and Their Applications, pp. 36–37 (2000)

    Google Scholar 

  • de Castro, L.N., Von Zuben, F.J.: aiNet: An artificial immune network for data analysis. In: Abbass, H.A., Sarker, R.A., Newton, C.S. (eds.) Data Mining: A Heuristic Approach, pp. 231–259. Idea Group Publishing, USA (2001)

    Google Scholar 

  • Farmer, J., Packard, N., Perelson, A.: The immune system, adaptation and machine learning. Physica D 22, 187–204 (1986)

    Google Scholar 

  • Holland, J.H.: Escaping brittleness: The possiblities of general purpose learning algorithms applied to parallel rule-based systems. In: Michalski, R.S., Carbonell, J.G., Mitchell, T.M. (eds.) Machine Learning 2, pp. 593–623. Kaufman, San Francisco (1976)

    Google Scholar 

  • Jerne, N.: Towards a network theory of the immune system. Annals of Immunology 125, 373–389 (1974)

    Google Scholar 

  • Kleinstein, S.H., Seiden, P.E.: Simulating the immune system. Computing in Science and Engineering, 69–77 (June/August 2000)

    Google Scholar 

  • Knight, T., Timmis, J.: AINE: An immunological approach to data mining. In: Cercone, N., Lin, T., Wu, X. (eds.) IEEE International Conference on Data Mining, San Jose, CA. USA, pp. 297–304 (2001)

    Google Scholar 

  • Kuipers, B.: Commonsense reasoning about causality: Deriving behavior from structure. Artificial Intelligence 24, 169–204 (1984)

    Article  Google Scholar 

  • Lydyard, P.M., Whelan, A., Fanger, M.W.: Instant Notes in Immunology. BIOS Scientific Publishers Ltd, New York (2000)

    Google Scholar 

  • Oudin, J., Cazenava, P.: Similar idiotopic specificities in immunoglobin fractions with different antibody functions or even without detectable antibody function. Proc. Natn. Acad. Sci. 68, 2616–2620 (1971)

    Article  Google Scholar 

  • Perelson, A.S., Weisbuch, G.: Immunology for physicists. Rev. Modern Phys. 69, 1219–1267 (1997)

    Article  Google Scholar 

  • Smith, D.J., Forrest, S., Perelson, A.S.: Immunological memory is associative. In: Int. Conference of Multiagent Systems, Kyoto, Japan, pp. 62–70 (1996); workshop Notes, Workshop 4: Immunity Based Systems

    Google Scholar 

  • Stadler, P.F., Schuster, P., Perelson, A.S.: Immune networks modelled by replicator equations. J. Math. Biol. 33, 111–137 (1994)

    Article  MATH  MathSciNet  Google Scholar 

  • Stewart, J., Varela, F.J.: Morphogensis in shape space. Elementary metadynamics in a model of the immune network. J. Theor. Biol. 153, 477–498 (1991)

    Article  Google Scholar 

  • Timmis, J., Neal, M., Hunt, J.: An artificial immune system for data analysis. Biosystems 55(1/3), 143–150 (2000)

    Article  Google Scholar 

  • Vertosick, F., Kelly, R.: The immune system as a neural network: A multi-epitope approach. Journal of Theoretical Biology 150, 225–237 (1991)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Garrett, S.M. (2003). A Paratope Is Not an Epitope: Implications for Immune Network Models and Clonal Selection. In: Timmis, J., Bentley, P.J., Hart, E. (eds) Artificial Immune Systems. ICARIS 2003. Lecture Notes in Computer Science, vol 2787. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45192-1_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-45192-1_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40766-9

  • Online ISBN: 978-3-540-45192-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics