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Structural Identifiability in Low-Rank Matrix Factorization

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Computing and Combinatorics (COCOON 2008)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5092))

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Abstract

In many signal processing and data mining applications, we need to approximate a given matrix Y of “sensor measurements” over several experiments by a low-rank product Y ≈ A·X, where X contains source signals for each experiment, A contains source-sensor mixing coefficients, and both A and X are unknown. We assume that the only a-priori information available is that A must have zeros at certain positions; this constrains the source-sensor network connectivity pattern.

In general, different AX factorizations approximate a given Y equally well, so a fundamental question is how the connectivity restricts the solution space. We present a combinatorial characterization of uniqueness up to diagonal scaling, called structural identifiability of the model, using the concept of structural rank from combinatorial matrix theory.

Next, we define an optimization problem that arises in the need for efficient experimental design: to minimize the number of sensors while maintaining structural identifiability. We prove its NP-hardness and present a mixed integer linear programming framework with two cutting-plane approaches. Finally, we experimentally compare these approaches on simulated instances of various sizes.

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References

  1. Boscolo, R., Sabatti, C., Liao, J., Roychowdhury, V.: A Generalized Framework for Network Component Analysis. IEEE Trans. Comp. Biol. Bioinf. 2, 289–301 (2005)

    Article  Google Scholar 

  2. Brunet, J.P., Tamayo, P., Golub, T.R., Mesirov, J.P.: Metagenes and Molecular Pattern Discovery Using Matrix Factorization. PNAS 101, 4164–4169 (2004)

    Article  Google Scholar 

  3. Garey, M., Johnson, D.: Computers and Intractability: A Guide to the Theory of NP-Completeness. W.H. Freeman and Company, New York (1979)

    MATH  Google Scholar 

  4. Hopcroft, J., Karp, R.: An n 5 / 2 Algorithm for Maximum Matchings in Bipartite Graphs. SIAM J. Comput. 2, 225–231 (1973)

    Article  MATH  MathSciNet  Google Scholar 

  5. Lee, D., Seung, H.: Learning the Parts of Objects by Non-negative Matrix Factorization. Nature 401, 788–791 (1999)

    Article  Google Scholar 

  6. Liao, J., Boscolo, R., Yang, Y.L., Tran, L., Sabatti, C., Roychowdhury, V.: Network Component Analysis: Reconstruction of Regulatory Signals in Biological Systems. PNAS 100, 15522–15527 (2003)

    Article  Google Scholar 

  7. Lin, C.J.: Projected Gradient Methods for Non-Negative Matrix Factorization. Neural Computation 19, 2756–2779 (2007)

    Article  MATH  MathSciNet  Google Scholar 

  8. Lovasz, L., Plummer, M.: Matching Theory. North-Holland, Amsterdam (1986)

    MATH  Google Scholar 

  9. Murota, K.: Matrices and Matroids for Systems Analysis. Springer, Heidelberg (2000)

    MATH  Google Scholar 

  10. Narasimhan, S., Rengaswamy, R., Vadigepalli, R.: Structural Properties of Gene Regulatory Networks: Definitions and Connections. IEEE Trans. Comp. Biol. Bioinf. (accepted, 2007)

    Google Scholar 

  11. Shahnaz, F., Berry, M., Pauca, V., Plemmons, R.: Document Clustering Using Nonnegative Matrix Factorization. Inf. Proc. & Manag. 42, 373–386 (2006)

    Article  MATH  Google Scholar 

  12. Wolsey, L.: Integer Programming. Wiley Interscience, Chichester (1998)

    MATH  Google Scholar 

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Xiaodong Hu Jie Wang

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Fritzilas, E., Rios-Solis, Y.A., Rahmann, S. (2008). Structural Identifiability in Low-Rank Matrix Factorization. In: Hu, X., Wang, J. (eds) Computing and Combinatorics. COCOON 2008. Lecture Notes in Computer Science, vol 5092. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69733-6_15

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  • DOI: https://doi.org/10.1007/978-3-540-69733-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69732-9

  • Online ISBN: 978-3-540-69733-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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