Abstract
Ventricular tachycardia and fibrillation are dangerous cardiac arrhythmias. Anti-arrhythmic drugs such as lidocaine (a class I drug) reinstate normal sinus rhythm, but they have pro-arrhythmic side effects and their mechanisms of action are poorly understood. We used computational models of human ventricular tissues to elucidate and quantify these mechanisms.
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Benson, A.P., Lawrenson, J.A., Gilbert, S.H., Holden, A.V. (2008). Quantifying Effects of Class I Anti-arrhythmic Drugs in Human Virtual Cardiac Tissues. In: Bello, F., Edwards, P.J.E. (eds) Biomedical Simulation. ISBMS 2008. Lecture Notes in Computer Science, vol 5104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70521-5_23
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DOI: https://doi.org/10.1007/978-3-540-70521-5_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-70520-8
Online ISBN: 978-3-540-70521-5
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