Abstract
Tumour size is an important prognostic indicator in breast cancer. This is typically measured as a simple linear diameter, although tumour volume may be a better surrogate of tumour burden. We have been optimizing techniques for three-dimensional histopathology based on digital scanning light microscopy of whole-mount, whole-specimen serial sections. We apply this to validate tumour volume measurements obtained using specimen cone-beam CT imaging. We demonstrate initial results for this technique using one lumpectomy and then show examples of how this technique can serve as a ‘gateway’ to validating emerging functional and molecular imaging modalities.
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Clarke, G.M. et al. (2008). Validation of Cone-Beam CT Measurements of Tumour Burden Using Three-Dimensional Histopathology: Initial Results For a Lumpectomy. In: Krupinski, E.A. (eds) Digital Mammography. IWDM 2008. Lecture Notes in Computer Science, vol 5116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70538-3_61
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DOI: https://doi.org/10.1007/978-3-540-70538-3_61
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-70537-6
Online ISBN: 978-3-540-70538-3
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