Abstract
This paper considers piecewise affine models of genetic regulatory networks and focuses on the problem of detecting switches among different modes of operation in gene expression data. This task constitutes the first step of a procedure for the complete identification of the network. We propose two methods and illustrate the application to the reconstruction of switching times in data produced by a piecewise affine model of the network regulating the carbon starvation response in Escherichia coli.
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Porreca, R., Ferrari-Trecate, G., Chieppi, D., Magni, L., Bernard, O. (2007). Switch Detection in Genetic Regulatory Networks. In: Bemporad, A., Bicchi, A., Buttazzo, G. (eds) Hybrid Systems: Computation and Control. HSCC 2007. Lecture Notes in Computer Science, vol 4416. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71493-4_77
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DOI: https://doi.org/10.1007/978-3-540-71493-4_77
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-71492-7
Online ISBN: 978-3-540-71493-4
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