Abstract
Our aim is to develop a framework to validate 3-D computer models of cardiac electrophysiology using measurements of action potential obtained via optical imaging (based on voltage-sensitive fluorescence), and heart anatomy and fiber directions which are obtained from magnetic resonance imaging (MRI). In this paper we present preliminary results of this novel framework using a healthy porcine heart ex vivo model and the Aliev & Panfilov mathematical model. This experimental setup will facilitate the testing, validation and adjustment of computational models prior to their integration into clinical applications.
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References
Kebler, A., Rudy, Y.: Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiological Review 84, 431–488 (2004)
Nash, M.P., Panfilov, A.V.: Electromechanical model of the excitable tissue to study reentrant cardiac arrhythmias. Progress in Biophys. Mol. Biol. 85, 501–510 (2004)
Clayton, R.H., Holden, A.V.: Dispersion of cardiac action potential duration and the initiation of re-entry: A computational study, Biomedical Eng. Online, pp. 4–11 (2005)
Aliev, R., Panfilov, A.V.: A simple two variables model of cardiac excitation. Chaos, Soliton and Fractals. 7(3), 293–301 (1996)
Aliev, R., Panfilov, A.V.: Modeling of heart excitation patterns caused by local inhomogeneity. Journal of Theoretical Biology 181, 33–40 (1996)
Kim, B.S., Kim, Y.H., Hwang, G.S., Pak, H.N., Lee, S.C., Shim, W.J., Oh, D.J., Ro, Y.M.: Action Potential duration restitution kinetics in human atrial fibrillation. Journal of the American College of Cardiology 39(8), 1329–1336 (2002)
Sermesant, M., Faris, O., Evans, F., McVeigh, E., Coudiere, Y., Delingette, H., Ayache, N.: Preliminary validation using in vivo measures of a macroscopic electrical model of the heart. In: Ayache, N., Delingette, H. (eds.) IS4TM 2003. LNCS, vol. 2673, pp. 230–243. Springer, Heidelberg (2003)
Efimov, I.R., Nikolski, V.P., Salama, G.: Optical imaging of the heart. Circulation Research. Jul 9 95(1), 21–33 (2004)
Kay, M.W., Amison, P.M., Rogers, J.M.: 3D surface reconstruction and panoramic optical mapping of large hearts. IEEE Trans. on Biomed. Eng. 51, 1219–1229 (2004)
Sung, D., Omens, J.H., McCulloch, A.D.: Model-based analysis of optically mapped epicardial patterns and conduction velocity. Ann. Biomed. Eng. 28, 1085–1092 (2000)
Chung, D., Pop, M., Sermesant, M., Wright, G.A.: Stereo reconstruction of the epicardium for optical fluorescence imaging. In: Esboll, BJ., Jorgensen, TM. (eds.) MICCAI Workshop on Biophotonics for diagnosis and treatment. IMM-Technical Report, pp. 33–40 (2006)
Horn, K.P.: Closed-form solution of absolute orientation using unit quaternions. Journal of the Optical Society of America A. 4, 629 (1987)
Helm, P., Tseng, H.J., Younes, L., McVeigh, E.R., Winslow, R.L.: Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure. Magnetic Resonance Medicine 54(4), 850–859 (2005)
Sermesant, M., Delingette, H., Ayache, N.: An Electromechanical model of the heart for image analysis and aimulation. IEEE Transactions on Medical Imaging 25(5), 612–625 (2006)
Elharrar, V., Surawicz, B.: Cycle length effect on restitution of action potential duration in dog cardiac fibers. Am. J. Physiology 244, H782–H792 (1983)
Moreau-Villeger, V., Delingette, H., Sermesant, M., Ashikaga, H., McVeigh, E.R., Ayache, N.: Building maps of local apparent conductivity of the epicardium with a 2-D electrophysiological model of the heart. IEEE Transactions on Biomedical Engineering 53(8), 1457–1466 (2006)
Bishop, M.J., Rodriguez, B., Eason, J., Whiteley, J.P., Trayanova, N., Gavaghan, D.J.: Synthesis of voltage-sensitive optical signals: Application to panoramic optical mapping. Biophysics J. 90, 2938–2945 (2006)
Hyatt, C.J., Mironov, S.F., Vetter, F.J., Zemlin, C.W., Pertsov, A.M.: Optical action potential upstroke morphology reveals near-surface transmural propagation direction. Circulation Research, 97, 277–284 (2005)
Vetter, F.J., Simons, S.B., Mironov, S., Hyatt, C.H., Pertsov, A.M.: Epicardial fiber organization in swine right ventricle and its impact on propagation. Circulation Research, 96, 244–251 (2005)
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Pop, M. et al. (2007). An Experimental Framework to Validate 3D Models of Cardiac Electrophysiology Via Optical Imaging and MRI. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_11
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DOI: https://doi.org/10.1007/978-3-540-72907-5_11
Publisher Name: Springer, Berlin, Heidelberg
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