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A Three Dimensional Ventricular E-Cell (3Dv E-Cell) with Stochastic Intracellular Ca 2 +  Handling

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Functional Imaging and Modeling of the Heart (FIMH 2007)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 4466))

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Abstract

To investigate the mechanisms underlying the initiation and propagation of intracellular Ca 2 +  waves, we developed a three-dimensional ventricular E-Cell (3Dv E-Cell), where cell membrane, nucleus, ryanodine receptor clusters, Z-disk, cytoplasm are modeled as spatially distributed structures. For the simulation of Ca 2 +  sparks and Ca 2 +  diffusion, a modified Fire-Diffuse-Fire model is used with stochastic rules for triggering Ca 2 +  release. The 3Dv E-Cell is used to illustrate how stochastic properties of Ca 2 +  sparks can lead to complex spatio-temporal intracellular wave processes and allows the incorporation of spatial data sets (protein distribution) into the geometry.

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Authors and Affiliations

  1. Institute of Membrane and Systems Biology and Cardiovascular Research Institute, University of Leeds, Leeds LS2 9JT, UK

    Pan Li, Matthew Lancaster & Arun V. Holden

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  1. Pan Li
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  2. Matthew Lancaster
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  3. Arun V. Holden
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Frank B. Sachse Gunnar Seemann

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© 2007 Springer Berlin Heidelberg

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Li, P., Lancaster, M., Holden, A.V. (2007). A Three Dimensional Ventricular E-Cell (3Dv E-Cell) with Stochastic Intracellular Ca 2 +  Handling. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_19

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  • DOI: https://doi.org/10.1007/978-3-540-72907-5_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-72906-8

  • Online ISBN: 978-3-540-72907-5

  • eBook Packages: Computer ScienceComputer Science (R0)

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