Abstract
We examine the effects of cardiac geometry and architecture on re-entrant scroll wave dynamics by quantifying the scroll wave filament in two biophysically-detailed heterogeneous models of the human left ventricular free wall – a simple cuboid model and a wedge model constructed using DT-MRI data. For any given geometry, changing the architecture results in changes to the filament meander pattern, increases in filament length, changes to the filament curvature and local filament twist, and increases in the maximum twist along a single filament. Changes to the geometry also affect scroll wave dynamics, mainly due to the size of the tissue. We conclude that such differences in re-entrant scroll wave dynamics should be taken into account when interpreting results from simulations that use simple cardiac geometries and architectures.
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Benson, A.P., Ries, M.E., Holden, A.V. (2007). Effects of Geometry and Architecture on Re-entrant Scroll Wave Dynamics in Human Virtual Ventricular Tissues. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_21
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DOI: https://doi.org/10.1007/978-3-540-72907-5_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72906-8
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