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Early Breast Cancer Prognosis Prediction and Rule Extraction Using a New Constructive Neural Network Algorithm

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Computational and Ambient Intelligence (IWANN 2007)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 4507))

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Abstract

Breast cancer relapse prediction is an important step in the complex decision-making process of deciding the type of treatment to be applied to patients after surgery. Some non-linear models, like neural networks, have been successfully applied to this task but they suffer from the problem of extracting the underlying rules, and knowing how the methods operate can help to a better understanding of the cancer relapse problem. A recently introduced constructive algorithm (DASG) that creates compact neural network architectures is applied to a dataset of early breast cancer patients with the aim of testing the predictive ability of the new method. The DASG method works with Boolean input data and for that reason a transformation procedure was applied to the original data. The degradation in the predictive performance due to the transformation of the data is also analyzed using the new method and other standard algorithms.

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References

  1. Biganzoli, E., Boracchi, P., Coradini, D., Daidone, M.E., Marubini, E.: Prognosis in Node-negative Primary Breast Cancer: a neural network analysis of risk profiles using routinely assessed factors. Annals of Oncology 14, 1484–1493 (2003)

    Article  Google Scholar 

  2. Jerez, J.M., Franco, L.E., Alba, E., Llombart-Cussac, A., Lluch, A., Ribelles, N., Munárriz, B., Martin, M.: Improvement of Breast Cancer Relapse Prediction in High Risk Intervals using Artificial Neural Networks. Breast Cancer Research and Treatment 94, 265–272 (2005)

    Article  Google Scholar 

  3. Subirats, J.L., Jerez, J.M., Franco, L.: A New Decomposition Algorithm for the Synthesis and Generalization of Boolean Functions. Submitted (2007)

    Google Scholar 

  4. Witten, I.H., Frank, E.: Data Mining: Practical machine learning tools with Java implementations. Morgan Kaufmann, San Francisco (2000)

    Google Scholar 

  5. Quinlan, J.R.: C4.5: Program for Machine Learning. Morgan Kaufmann, San Mateo (1993)

    Google Scholar 

  6. Tilbury, J.B., Van Eetvelt, W.J., Garibaldi, J.M., Curnsw, J.S.H., Ifeachor, E.C.: Receiver operating characteristic analysis for intelligent medical systems-a new approach for finding confidence intervals. IEEE Trans. on Biomedical Engineering 47, 952–963 (2000)

    Article  Google Scholar 

  7. Lisboa, P.J.G., Vellido, A., Wong, H.: Outstanding Issues for Clinical Decision Support with Neural Networks. In: Artificial Neural Networks in Medicine and Biology, pp. 63–71. Springer, London (2000)

    Google Scholar 

  8. Fawcett, T.: ROC graphs: Notes and practical considerations for researchers. Technical report, HP Laboratories (2004)

    Google Scholar 

  9. Saphner, T., Tormey, D.C., Gray, R.: Annual hazard rates of recurrence for breast cancer after primary therapy. Journal of Clinical Oncology 14, 2738–2746 (1996)

    Google Scholar 

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Francisco Sandoval Alberto Prieto Joan Cabestany Manuel Graña

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© 2007 Springer-Verlag Berlin Heidelberg

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Franco, L., Subirats, J.L., Molina, I., Alba, E., Jerez, J.M. (2007). Early Breast Cancer Prognosis Prediction and Rule Extraction Using a New Constructive Neural Network Algorithm. In: Sandoval, F., Prieto, A., Cabestany, J., Graña, M. (eds) Computational and Ambient Intelligence. IWANN 2007. Lecture Notes in Computer Science, vol 4507. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73007-1_121

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  • DOI: https://doi.org/10.1007/978-3-540-73007-1_121

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-73006-4

  • Online ISBN: 978-3-540-73007-1

  • eBook Packages: Computer ScienceComputer Science (R0)

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