Skip to main content

Toward an Integrated RNA Motif Database

  • Conference paper
Data Integration in the Life Sciences (DILS 2007)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 4544))

Included in the following conference series:

  • 716 Accesses

Abstract

In this paper we present the design and implementation of an RNA structural motif database, called RmotifDB. The structural motifs stored in RmotifDB come from three sources: (1) collected manually from biomedical literature; (2) submitted by scientists around the world; and (3) discovered by a wide variety of motif mining methods. We present here a motif mining method in detail. We also describe the interface and search mechanisms provided by RmotifDB as well as techniques used to integrate RmotifDB with the Gene Ontology. The RmotifDB system is fully operational and accessible on the Internet at http://datalab.njit.edu/bioinfo/

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Akmaev, V.R., Kelley, S.T., Stormo, G.D.: Phylogenetically enhanced statistical tools for RNA structure prediction. Bioinformatics 16, 501–512 (2000)

    Article  Google Scholar 

  2. Bakheet, T., Frevel, M., Williams, B.R., Greer, W., Khabar, K.S.: ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res. 29, 246–254 (2001)

    Article  Google Scholar 

  3. Bindewald, E., Shapiro, B.A.: RNA secondary structure prediction from sequence alignments using a network of k-nearest neighbor classifiers. RNA 12, 342–352 (2006)

    Article  Google Scholar 

  4. Bindewald, E., Schneider, T.D., Shapiro, B.A.: CorreLogo: an online server for 3D sequence logos of RNA and DNA alignments. Nucleic Acids Res. 34, 405–411 (2006)

    Article  Google Scholar 

  5. Cohen.-Boulakia, S., Davidson, S.B., Froidevaux, C.: A user-centric framework for accessing biological sources and tools. In: Proc. of the 2nd International Workshop on Data Integration in the Life Sciences, pp. 3–18 (2005)

    Google Scholar 

  6. Dalgaard, P.: Introductory Statistics with R. Springer, Heidelberg (2004)

    Google Scholar 

  7. Davidson, S.B., Crabtree, J., Brunk, B.P., Schug, J., Tannen, V., Overton, G.C., Stoeckert Jr., C.J.: K2/Kleisli and GUS: experiments in integrated access to genomic data sources. IBM Systems Journal 40, 512–531 (2001)

    Google Scholar 

  8. Eddy, S.R.: A memory-efficient dynamic programming algorithm for optimal alignment of a sequence to an RNA secondary structure. BMC Bioinformatics 3(18) (2002)

    Google Scholar 

  9. Gorodkin, J., Stricklin, S.L., Stormo, G.D.: Discovering common stem-loop motifs in unaligned RNA sequences. Nucleic Acids Res. 29, 2135–2144 (2001)

    Article  Google Scholar 

  10. Grillo, G., Licciulli, F., Liuni, S., Sbisa, E., Pesole, G.: PatSearch: a program for the detection of patterns and structural motifs in nucleotide sequences. Nucleic Acids Res. 31, 3608–3612 (2003)

    Article  Google Scholar 

  11. Hofacker, I.L.: Vienna RNA secondary structure server. Nucleic Acids Res. 31, 3429–3431 (2003)

    Article  Google Scholar 

  12. Jones, S.G., Moxon, S., Marshall, M., Khanna, A., Eddy, S.R., Bateman, A.: Rfam: annotating non-coding RNAs in complete genomes. Nucleic Acids Res. 33,D121–D124 (2005)

    Article  Google Scholar 

  13. Khaladkar, M., Bellofatto, V., Wang, J.T.L., Tian, B., Zhang, K.: RADAR: an interactive web-based toolkit for RNA data analysis and research. In: Proc. of the 6th IEEE Symposium on Bioinformatics and Bioengineering, pp. 209–212. IEEE Computer Society Press, Los Alamitos (2006)

    Chapter  Google Scholar 

  14. Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P., Burge, C.B.: Prediction of mammalian microRNA targets. Cell. 115, 787–798 (2003)

    Article  Google Scholar 

  15. Liu, J., Wang, J.T.L., Hu, J., Tian, B.: A method for aligning RNA secondary structures and its application to RNA motif detection. BMC Bioinformatics 6(89) (2005)

    Google Scholar 

  16. Mignone, F., Grillo, G., Licciulli, F., Iacono, M., Liuni, S., Kersey, P.J., Duarte, J., Saccone, C., Pesole, G.: UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res. 33, 141–146 (2005)

    Article  Google Scholar 

  17. Pruitt, K.D., Katz, K.S., Sicotte, H., Maglott, D.R.: Introducing RefSeq and LocusLink: curated human genome resources at the NCBI. Trends Genet 16, 44–47 (2000)

    Article  Google Scholar 

  18. Wang, J.T.L., Rozen, S., Shapiro, B.A., Shasha, D., Wang, Z., Yin, M.: New techniques for DNA sequence classification. Journal of Computational Biology 6, 209–218 (1999)

    Google Scholar 

  19. Wang, J.T.L., Shapiro, B.A., Shasha, D., Zhang, K., Currey, K.M.: An algorithm for finding the largest approximately common substructures of two trees. IEEE Transactions on Pattern Analysis and Machine Intelligence 20, 889–895 (1998)

    Article  Google Scholar 

  20. Wang, J.T.L., Wu, X.: Kernel design for RNA classification using support vector machines. International Journal of Data Mining and Bioinformatics 1, 57–76 (2006)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Sarah Cohen-Boulakia Val Tannen

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Berlin Heidelberg

About this paper

Cite this paper

Wang, J.T.L., Wen, D., Shapiro, B.A., Herbert, K.G., Li, J., Ghosh, K. (2007). Toward an Integrated RNA Motif Database. In: Cohen-Boulakia, S., Tannen, V. (eds) Data Integration in the Life Sciences. DILS 2007. Lecture Notes in Computer Science(), vol 4544. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73255-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-73255-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-73254-9

  • Online ISBN: 978-3-540-73255-6

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics