Abstract
The particular molecular-scale devices that are the topic of this article are known as DNA nanostructures. As will be explained, DNA nanostructures have some unique advantages among nanostructures: they are relatively easy to design, fairly predictable in their geometric structures, and have been experimentally implemented in a growing number of labs around the world. They are constructed primarily of synthetic DNA. A key principle in the study of DNA nanostructures is the use of self-assembly processes to actuate the molecular assembly. Since self-assembly operates naturally at the molecular scale, it does not suffer from the limitation in scale reduction that so restricts lithography or other more conventional top-down manufacturing techniques.
Supported by NSF grants CCF-0523555, CCF-0432038, CCF-0432047. An extended version of this paper is at http://www.cs.duke.edu/~reif/paper/AutonomousDNA/ AutonomousDNA.pdf
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Reif, J.H., LaBean, T.H. (2007). Autonomous Programmable Biomolecular Devices Using Self-assembled DNA Nanostructures. In: Leivant, D., de Queiroz, R. (eds) Logic, Language, Information and Computation. WoLLIC 2007. Lecture Notes in Computer Science, vol 4576. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73445-1_21
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