Abstract
A novel in vitro mock circulatory system, which enables to reproduce an inflow restriction, simulating blood volume pooling due to heart failure, was developed to evaluate a hydrodynamic performance of a pulsatile ventricular assist device (VAD) in practical conditions. The concept of this development was motivated by a difference of an inflow restriction between in vitro and in vivo environments. The major idea of this study is to reproduce an inflow restriction by using a centrifugal pump placed at an inflow side of a left ventricular model instead of a constant head reservoir in a conventional circuit. In the novel circuit, the maximum flow rate was obtained at lower systolic fraction as compared with a conventional circuit. This similar tendency by the novel one was observed in an acute animal experiment in sheep. This result suggests that a new mock circuit is effective to confirm a practical drive strategy of the VAD for various diseased conditions.
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© 2007 Springer-Verlag Berlin Heidelberg
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Furusato, M. et al. (2007). A Reproduction of Inflow Restriction in the Mock Circulatory System to Evaluate a Hydrodynamic Performance of a Ventricular Assist Device in Practical Conditions. In: Li, K., Li, X., Irwin, G.W., He, G. (eds) Life System Modeling and Simulation. LSMS 2007. Lecture Notes in Computer Science(), vol 4689. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74771-0_63
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DOI: https://doi.org/10.1007/978-3-540-74771-0_63
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-74770-3
Online ISBN: 978-3-540-74771-0
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