Abstract
Molecular imaging can detect abnormal functions of living tissue. Functional abnormality in gene expression or metabolism can be represented as altered volume or probe intensity. Accurate measurement of volume and probe intensity in tissue mainly relies on image segmentation techniques. Thus, segmentation is a critical technique in quantitative analysis. We developed an automatic object marker-driven three dimensional(3D) watershed transform for quantitative analysis of functional images. To reduce the discretization error in volume measurement less than 5%, the size criteria for digital spheres were investigated to provide the minimum volume. When applied to SPECT images, our segmentation technique produced 89% or higher accuracy in the volume and intensity of tumors and also showed high correlation with the ground truth segmentation (ρ> 0.93). The developed 3D method did not require interactive object marking and offered higher accuracy than a 2D watershed approach. Furthermore, it computed faster than the segmentation technique based on the marker-driven gradient modification.
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Kim, K., Lee, M., Park, H., Kim, J.H., Kim, S., Chung, H., Choi, K., Kim, I.S., Seong, B.L., Kwon, I.C.: Cell-Permeable and Biocompatible Polymeric Nanoparticles for Apoptosis Imaging. Journal of the American Chemical Society 128, 3490–3491 (2006)
Digabel, H., Lantuéjoul, C.: Iterative Algorithms. In: Chermant, J.L. (ed.) Proc. 2nd European Symp. on Quantitative Anal. Microstructures in Material Science, Biology and Medicine, West Germany, pp. 85–99 (October 1977)
Beucher, S., Lantuéjoul, C.: Use of Watersheds in Contour Detection. In: Proc. Int. Workshop on Image Processing, Real-Time Edge and Motion Detection/Estimation, Rennes, France, pp. 17–21 (September 1979)
Vincent, L., Soille, P.: Watersheds in Digital Spaces: An Efficient Algorithm Based on Immersion Simulations. IEEE Trans. Patt. Anal. Mach. Int. 13, 583–598 (1991)
Kim, D.: Multiresolutional Watershed Segmentation with User-Guided Grouping. The International Society for Optical Engineering (SPIE), Medical Imaging 1998, San Diego, CA, pp. 1087–1095, (February 1998)
Serra, J., Vincent, L.: An Overview of Morphological Filtering. Circuits Systems Signal Process 11, 47–108 (1992)
Roerdink, J.B.T.M., Meijster, A.: The Watershed Transform: Definitions, Algorithms and Parallelization. Fundamenta Informaticae 41, 187–228 (2000)
Yim, P.J., Kim, D., Lucas, C.: A High-Resolution Four-Dimensional Surface Reconstruction of the Right Heart and Pulmonary Arteries. The International Society for Optical Engineering (SPIE), Medical Imaging, San Diego, CA , pp. 726–738 (February 1998)
Gonzalez, R.C, Woods, R.E.: Digital Image Processing, 2nd edn. Prentice Hall, Englewood Cliffs (2002)
Bresenham, J.: A Linear Algorithm for Incremental Display of Circular Arcs. Communications of the ACM 20, 100–106 (1977)
Kennedy, J.: A Fast Bresenham Type Algorithm for Drawing Circles. Available at: http://homepage.smc.edu/kennedy_john/BCIRCLE.PDF
Available at: http://www.med.harvard.edu/AANLIB/cases/case1/case.html
Sijbers, J., Scheunders, P., Verhoye, M., van der Linden, A., van Dyck, D., Raman, E.: Watershed-Based Segmentation of 3D MR Data for Volume Quantization. Magnetic Resonance Imaging 15(6), 679–688 (1997)
Grau, V., Kikinis, R., Alcaniz, M., Warfield, S.K.: Cortical Gray Matter Segmentation Using an Improved Watershed-Transform. Engineering in Medicine and Biology Society, 2003. In: Proceedings of the 25th Annual International Conference of the IEEE, vol. 1, pp. 618–621 (September 2003)
Lapeer, R.J., Tan, A.C., Aldridge, R.V.: A Combined Approach to 3D Medical Image Segmentation Using Marker-based Watersheds and Active Contours: The Active Watershed Method. In: Medical Image Understanding - MIUA 2002, Proceedings, pp. 165–168 (2002)
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Chae, Ys., Kim, D. (2007). Automatic Marker-Driven Three Dimensional Watershed Transform for Tumor Volume Measurement. In: Szczuka, M.S., et al. Advances in Hybrid Information Technology. ICHIT 2006. Lecture Notes in Computer Science(), vol 4413. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77368-9_15
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DOI: https://doi.org/10.1007/978-3-540-77368-9_15
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