Abstract
The reductionist approaches of molecular and cellular biology have produced revolutionary advances in our understanding of biological function and information processing. The difficulty associated with relating molecular components to their systemic function led to the development of systems biology, a relatively new field that aims to establish a bridge between molecular level information and systems level understanding. The novelty of systems biology lies in the emphasis on analyzing complexity in networked biological systems using integrative rather than reductionist approaches. By its very nature, systems biology is a highly interdisciplinary field that requires the effective collaboration of scientists and engineers with different technical backgrounds, and the interdisciplinary training of students to meet the rapidly evolving needs of academia, industry, and government. This chapter summarizes state-of-the-art developments of automatic control in systems biology with substantial theoretical background and illustrative examples.
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Abbreviations
- 2-D:
-
two-dimensional
- BST:
-
biochemical systems theory
- CME:
-
chemical master equation
- DISC:
-
death inducing signalling complex
- FBA:
-
flux balance analysis
- FIM:
-
Fisher information matrix
- GLUT4:
-
activated Akt and PKCζ trigger glucose transporter
- IRS1:
-
insulin receptor substrate-1
- MPA:
-
metabolic pathway analysis
- MPC:
-
model-based predictive control
- ODE:
-
ordinary differential equation
- P/T:
-
place/transition
- PI3K:
-
phosphatidylinositol-3-kinase
- PRC:
-
phase response curve
- SCN:
-
suprachiasmatic nucleus
- SIM:
-
single input module
- SNA:
-
structural network analysis
- SSA:
-
stochastic simulation algorithm
- Smac:
-
second mitochondrial-activator caspase
- TU:
-
transcriptional unit
- WWW:
-
World Wide Web
- XIAP:
-
X-linked inhibitor of apoptosis protein
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© 2009 Springer-Verlag Berlin Heidelberg
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Mirsky, H. et al. (2009). Automatic Control in Systems Biology. In: Nof, S. (eds) Springer Handbook of Automation. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78831-7_75
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