Abstract
A combined analysis by integrating the resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) is presented in this paper to investigate the structure-function relationship in early-onset schizophrenia. After fractional anisotropy in white matter was assessed, functional connectivity was analyzed with regions of reference which was defined according to the regions showed lower fractional anisotropy values. We found significant decreased functional connectivity in early-onset schizophrenia correlated with the regions of anisotropy changes. Our results demonstrated that the white matter lesions may disrupt the anatomical connectivity and inflect the functional connectivity between the frontal regions and other brain regions.
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Ke, M., Huang, X., Shen, H., Zhou, Z., Chen, X., Hu, D. (2008). Combined Analysis of Resting-State fMRI and DTI Data Reveals Abnormal Development of Function-Structure in Early-Onset Schizophrenia. In: Wang, G., Li, T., Grzymala-Busse, J.W., Miao, D., Skowron, A., Yao, Y. (eds) Rough Sets and Knowledge Technology. RSKT 2008. Lecture Notes in Computer Science(), vol 5009. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79721-0_84
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DOI: https://doi.org/10.1007/978-3-540-79721-0_84
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