Abstract
A combined analysis by integrating the resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) is presented in this paper to investigate the structure-function relationship in early-onset schizophrenia. After fractional anisotropy in white matter was assessed, functional connectivity was analyzed with regions of reference which was defined according to the regions showed lower fractional anisotropy values. We found significant decreased functional connectivity in early-onset schizophrenia correlated with the regions of anisotropy changes. Our results demonstrated that the white matter lesions may disrupt the anatomical connectivity and inflect the functional connectivity between the frontal regions and other brain regions.
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References
Niznikiewicz, M.A., Kubicki, M., Shenton, M.E.: Recent structural and functional imaging findings in schizophrenia. Current Opinion in Psychiatry 16, 123–147 (2003)
Raichle, M.E., Mintun, M.A.: Brain work and brain imaging. Annu. Rev. Neurosci. 29, 449–476 (2006)
Buckner, R.L., Vincent, J.L.: Unrest at rest: the importance of default activity and spontaneous network correlations. NeuroImage 37, 1091–1096 (2007)
Malaspina, D., Harkavy-Friedman, J., Corcoran, C., Mujica-Parodi, L., Printz, D., Gorman, J.M., Heertum, R.V.: Resting neural activity distinguishes subgroups of schizophrenia patients. Biol. Psychiatry 56, 931–937 (2004)
Kanaan, R.A.A., Kim, J., Kaufmann, W.E., Pearlson, G.D., Barker, G.J., McGuire, P.K.: Diffusion tensor imaging in schizophrenia. Biol. Psychiatry 58, 921–929 (2005)
Basser, P.J., Pierpaoli, C.: Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J. Magn. Reson. B. 111, 209–219 (1996)
Beaulieu, C.: The basis of anisotropic water diffusion in the nervous system—a technical review. NMR Biomed 15, 435–455 (2002)
Toosy, A.T., Ciccarelli, O., Parker, G.J.M., Wheeler-Kingshott, C.A.M., Miller, D.H., Thompson, A.J.: Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging. NeuroImage 21, 1452–1463 (2004)
Baird, A.A., Colvin, M.K., VanHorn, J.D., Inati, S., Gazzaniga, M.S.: Functional connectivity: Integrating behavioral, diffusion tensor imaging, and functional magnetic resonance imaging data sets. J. Cognitive Neuroscience. 17, 687–693 (2005)
Schlösser, R.G.M., Nenadic, I., Wagner, G., Güllmar, D., von Consbruch, K., Köhler, S., Schultz, C.C., Koch, K., Fitzek, C., Matthews, P.M., Reichenbach, J.R., Sauer, H.: White matter abnormalities and brain activation in schizophrenia: A combined DTI and fMRI study. Schizophrenia Research 89, 1–11 (2007)
Rhinewine, J.P., Lencz, T., Thaden, E.P., Cervellione, K.L., Burdick, K.E., Henderson, I., Bhaskar, S., Keehlisen, L., Kane, J., Kohn, N., Fisch, G.S., Bilder, R.M., Kumra, S.: Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlates. Biol. Psychiatry 58, 705–712 (2005)
Nicolson, R., Rapoport, J.L.: Childhood-onset schizophrenia: rare but worth Studying. Biol. Psychiatry 46, 1418–1428 (1999)
White, T., Kendi, A.T.K., Lehéricy, S., Kendi, M., Karatekin, C., Guimaraes, A., Davenport, N., Schulz, S.C., Lim, K.O.: Disruption of hippocampal connectivity in children and adolescents with schizophrenia– A voxel-based diffusion tensor imaging study. Schizophrenia Research 90, 302–307 (2007)
Stejskal, E.O., Tanner, J.E.: Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 42, 288–292 (1965)
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N., Friston, K.J., Frackowiak, R.S.: A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 14, 21–36 (2001)
Maldjian, J.A., Laurienti, P.J., Kraft, R.A., Burdette, J.H.: An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 19, 1233–1239 (2003)
Kubicki, M., Westin, C., McCariley, R.W., Shenton, M.E.: The application of DTI to investigate white matter abnormalities in schizophrenia. Ann. N.Y. Acad. Sci. 1064, 134–148 (2005)
Biswal, B., Yetkin, F.Z., Haughton, V.M., Hyde, J.S.: Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 34, 537–541 (1995)
Fallon, J.H., Opole, I.O., Potkin, S.G.: The neuroanatomy of schizophrenia: circuitry and neurotransmitter systems. Clinical Neuroscience Research 3, 77–107 (2003)
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Ke, M., Huang, X., Shen, H., Zhou, Z., Chen, X., Hu, D. (2008). Combined Analysis of Resting-State fMRI and DTI Data Reveals Abnormal Development of Function-Structure in Early-Onset Schizophrenia. In: Wang, G., Li, T., Grzymala-Busse, J.W., Miao, D., Skowron, A., Yao, Y. (eds) Rough Sets and Knowledge Technology. RSKT 2008. Lecture Notes in Computer Science(), vol 5009. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79721-0_84
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DOI: https://doi.org/10.1007/978-3-540-79721-0_84
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