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The Perils of Polynucleotides Revisited

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Algorithmic Bioprocesses

Part of the book series: Natural Computing Series ((NCS))

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Abstract

DNA computing relies on the successful implementation of physical chemistry techniques involving oligonucleotides of prescribed sequence. Our laboratory has been involved in the assembly and manipulation of designed oligonucleotides in order to pursue studies in genetic recombination and nanofabrication. We have constructed a large number of unusual branched DNA motifs used to build a variety of DNA objects, lattices, and nanomechanical devices. Our experience with these systems has uncovered a large number of experimental pitfalls that may confront individuals working with DNA-based computation. A decade ago, we presented our experience in this area in the hope that we could help investigators to anticipate experimental problems that affect DNA computing schemes. Here, we review these points from the vantage point of further experience, indicating both modifications to the original criteria and new points as well.

...that to which we return with the greatest pleasure possesses the greatest power...

Samuel Taylor Coleridge

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Author information

Authors and Affiliations

  1. Department of Chemistry, New York University, New York, NY, 10003, USA

    Nadrian C. Seeman

Authors
  1. Nadrian C. Seeman
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Correspondence to Nadrian C. Seeman .

Editor information

Editors and Affiliations

  1. Dept. Computer Science, University of British Columbia, Main Mall 201-2366, Vancouver, V6T 1Z4, Canada

    Anne Condon

  2. Dept. Applied Mathematics, Weizmann Institute of Science, Rehovot, 76100, Israel

    David Harel

  3. Leiden Inst. Advanced Computer Science, Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, Netherlands

    Joost N. Kok

  4. Turku Centre for Computer Science, Lemminkaisenkatu 14 A, Turku, 20520, Finland

    Arto Salomaa

  5. Computer Science, Computation,, California Inst. of Technology, Pasadena, 91125, U.S.A.

    Erik Winfree

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© 2009 Springer-Verlag Berlin Heidelberg

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Seeman, N.C. (2009). The Perils of Polynucleotides Revisited. In: Condon, A., Harel, D., Kok, J., Salomaa, A., Winfree, E. (eds) Algorithmic Bioprocesses. Natural Computing Series. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88869-7_12

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  • DOI: https://doi.org/10.1007/978-3-540-88869-7_12

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-88868-0

  • Online ISBN: 978-3-540-88869-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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