Abstract
In order to study the growth and development of cellular systems one needs a formalism in which one can combine the biophysical properties of cells with the modulation of these properties by gene regulatory processes. I will argue that the multiscale CA formalism now known as the Cellular Potts Model (CPM) provides a simple yet basically sound representation of a biological cell, which can be interfaced with gene regulatory processes. It represents a cell as a highly deformable object which takes its shape from internal and external forces acting upon it. I will demonstrate how within this formalism complex large scale morphodynamic processes can result from local regulation of cell, and in particular membrane, properties. I will explain morphogenetic mechanisms which tend to evolve in such systems.
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Hogeweg, P. (2009). Multilevel Modeling of Morphogenesis. In: Corne, D.W., Frisco, P., Păun, G., Rozenberg, G., Salomaa, A. (eds) Membrane Computing. WMC 2008. Lecture Notes in Computer Science, vol 5391. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-95885-7_3
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DOI: https://doi.org/10.1007/978-3-540-95885-7_3
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