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Evolution of Intracellular Ca2 +  Waves from about 10,000 RyR Clusters: Towards Solving a Computationally Daunting Task

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Functional Imaging and Modeling of the Heart (FIMH 2009)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 5528))

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Abstract

Detailed knowledge of spatial-temporal behaviours of intracellular calcium dynamics is very important in understanding excitation-contraction coupling of cardiac myocytes under both normal and pathological conditions, such as initiation and propagation of spontaneous calcium waves. A full cell simulation integrating about 10,000 Ca2 +  release units (CRUs) in a typical cardiac myocyte is considered a multi-scale, computationally demanding problem. In this paper, we imported an experimentally obtained spatial distribution of Ryanodine Receptor (RyR) clusters into a spatially extended, stochastic model of intracellular Ca2 +  dynamics, to investigate the role of the structural bifurcation of Z-disks on the initiation and propagation of intracellular Ca2 +  waves from spatially symmetric Ca2 +  sparks. Besides, we also proposed a simple parallelization strategy to increase computational speed for this chanllenging problem in cardiac modelling.

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Authors and Affiliations

  1. Center of Biomedical Computing, Simula research laboratory, 1325, Lysaker, Norway

    Pan Li, Wenjie Wei & Xing Cai

  2. Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand

    Christian Soeller & Mark B. Cannell

  3. Computational Biology Laboratory, Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom

    Arun V. Holden

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  1. Pan Li
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  2. Wenjie Wei
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  3. Xing Cai
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  4. Christian Soeller
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  5. Mark B. Cannell
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  6. Arun V. Holden
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Editors and Affiliations

  1. Asclepios Team, INRIA, 2004 route des Lucioles, 06902, Sophia-Antipolis BP 93, France

    Nicholas Ayache

  2. Asclepios Research Project, INRIA Sophia Antipolis, 2004 route des Lucioles, BP 93, 06902, Sophia Antipolis Cedex, France

    Hervé Delingette

  3. Asclepios Team, INRIA Sophia Antipolis, France

    Maxime Sermesant

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© 2009 Springer-Verlag Berlin Heidelberg

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Li, P., Wei, W., Cai, X., Soeller, C., Cannell, M.B., Holden, A.V. (2009). Evolution of Intracellular Ca2 +  Waves from about 10,000 RyR Clusters: Towards Solving a Computationally Daunting Task. In: Ayache, N., Delingette, H., Sermesant, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2009. Lecture Notes in Computer Science, vol 5528. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01932-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-01932-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01931-9

  • Online ISBN: 978-3-642-01932-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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