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The Importance of Model Parameters and Boundary Conditions in Whole Organ Models of Cardiac Contraction

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Functional Imaging and Modeling of the Heart (FIMH 2009)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 5528))

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Abstract

We have developed a model of active contraction in the whole heart, using an anatomical geometry of a failing human heart, fitted to MRI data. Deformation in this model was driven by a model of active tension generation in human ventricular myocytes. By perturbing model parameters and boundary conditions we have predicted which metrics of cardiac function are sensitive to different parameters or boundary conditions. This allows us to begin to identify parameters that can be determined from different diagnostic modalities.

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Authors and Affiliations

  1. Computing Laboratory, University of Oxford, Wolfson Building, Parks Road, Oxford, OX1 3QD, UK

    Steven Niederer & Nic Smith

  2. King’s College London, Division of Imaging Sciences, The Rayne Institute 4th Floor, Lambeth Wing, St Thomas’ Hospital, London, SE1 7EH, UK

    Kawal Rhode & Reza Razavi

Authors
  1. Steven Niederer
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  2. Kawal Rhode
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  3. Reza Razavi
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  4. Nic Smith
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Editor information

Editors and Affiliations

  1. Asclepios Team, INRIA, 2004 route des Lucioles, 06902, Sophia-Antipolis BP 93, France

    Nicholas Ayache

  2. Asclepios Research Project, INRIA Sophia Antipolis, 2004 route des Lucioles, BP 93, 06902, Sophia Antipolis Cedex, France

    Hervé Delingette

  3. Asclepios Team, INRIA Sophia Antipolis, France

    Maxime Sermesant

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© 2009 Springer-Verlag Berlin Heidelberg

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Niederer, S., Rhode, K., Razavi, R., Smith, N. (2009). The Importance of Model Parameters and Boundary Conditions in Whole Organ Models of Cardiac Contraction. In: Ayache, N., Delingette, H., Sermesant, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2009. Lecture Notes in Computer Science, vol 5528. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01932-6_38

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  • DOI: https://doi.org/10.1007/978-3-642-01932-6_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01931-9

  • Online ISBN: 978-3-642-01932-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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