Abstract
Mechanical load plays an important role in cardiac growth and remodeling. In a previous mathematical model study the hypothesis was tested that fiber cross-fiber shear acts as a stimulus for remodeling of the pattern of myofiber orientations [7]. It was found that reorientation in response to fiber cross-fiber shear yielded realistic longitudinal and transmural components of myofiber orientation. In this study, we investigated whether circumferential-radial shear, as determined experimentally with magnetic resonance tagging, can be reproduced in the model as well. Our results show that after myofiber reorientation differences in circumferential-radial shear between model and experiment were reduced significantly. However, a complete match could not be obtained through shear-induced myofiber reorientation alone.
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References
Axel, L., Dougherty, L.: MR imaging of motion with spatial modulation of magnetization. Am. J. Physiol. Heart. Circ. Physiol. 171, 841–845 (1989)
Bovendeerd, P.H., Huyghe, J.M., Arts, T., van Campen, D.H., Reneman, R.S.: Influence of endocardial-epicardial crossover of muscle fibers on left ventricular wall mechanics. J. Biomech. 27, 941–951 (1994)
Bovendeerd, P.H., Rijcken, J., van Campen, D.H., Schoofs, A.J.G., Nicolay, K., Arts, T.: Optimization of left ventricular muscle fiber orientation. In: Pedersen, P., Bendsøe, P. (eds.) Proc. IUTAM Symposium on Synthesis on Bio Solid Mechanics, Copenhagen, Denmark, pp. 285–295 (1998)
Dokos, S., Smaill, B.H., Young, A.A., LeGrice, I.J.: Shear properties of passive ventricular myocardium. Am. J. Physiol. Heart. Circ. Physiol. 283, H2650–H2659 (2002)
Geerts, L., Bovendeerd, P., Nicolay, K., Arts, T.: Characterization of the normal cardiac myofiber field in goat measured with MR-diffusion tensor imaging. Am. J. Physiol. Heart. Circ. Physiol. 283, H139–H145 (2002)
Kerckhoffs, R.C., Bovendeerd, P.H., Kotte, J.C., Prinzen, F.W., Smits, K., Arts, T.: Homogeneity of cardiac contraction despite physiological asynchrony of depolarization: a model study. Ann. Biomed. Eng. 31, 536–547 (2003)
Kroon, W., Delhaas, T., Bovendeerd, P., Arts, T.: Computational analysis of the myocardial structure: Adaptation of cardiac myofiber orientations through deformation. Med. Imag. Anal. (2008), doi:10.1016/j.media.2008.06.015
Lin, D.H., Yin, F.C.: A mulitaxial constitutive law for mamalian left ventricular myocardium in steady-state barium contracture or tetanus. J. Biomech. Eng. 120, 504–517 (1998)
MacKenna, D., Summerour, S.R., Villarreal, F.J.: Role of mechanical factors in regulating fibroblast function and extracellular matrix synthesis. Cardiovasc. Res. 46, 257–263 (2000)
Malvern, L.E.: Introduction of the mechanics of a contious medium. Prentice-Hall Inc., Englewood Cliffs (1969)
Rodriguez, E.K., Omens, J.H., Waldman, L.W., McCulloch, A.D.: Effect of residual stress on transmural sarcomere length distributions in rat left ventricle. Am. J. Physiol. Heart Circ. Physiol. 264, H1048–H1056 (1993)
Simpson, D.G., Majeski, M., Borg, T.K., Terracio, L.: Regulation of cardiac myocyte protein turnover and myofibrillar structure in vitro by specific directions of stretch. Circ. Res. 85, e59–e69 (1999)
Ubbink, S.W., Bovendeerd, P.H., Delhaas, T., Arts, T., van de Vosse, F.N.: Towards model based analysis of cardiac MR tagging data: relation between left ventricular shear strain and myofiber orientation. Med. Imag. Anal. 10, 632–641 (2006)
Usyk, T.P., Mazhari, R., McCulloch, A.D.: Effect of laminar orthotropic myofiber architecture on regional stress and strain in the canine left ventricle. J. Elast. 61, 143–164 (2000)
Van der Toorn, A., Barenbrug, P., Snoep, G., Van der Veen, F.H., Delhaas, T., Prinzen, F.W., Maessen, J., Arts, T.: Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI tagging. Am. J. Physiol. Heart. Circ. Physiol. 283, H1609–H1615 (2002)
Young, A.A., Kramer, C.M., Ferrari, V.A., Axel, L., Reichek, N.: Three-dimensional left ventricular deformation in hypertrophic cardiomyopathy. Circ. 90, 854–867 (1994)
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Kroon, W., Delhaas, T., Bovendeerd, P., Arts, T. (2009). Adaptive Reorientation of Cardiac Myofibers: Comparison of Left Ventricular Shear in Model and Experiment. In: Ayache, N., Delingette, H., Sermesant, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2009. Lecture Notes in Computer Science, vol 5528. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01932-6_7
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DOI: https://doi.org/10.1007/978-3-642-01932-6_7
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