Abstract
It has been suggested that the cooperation between spatial and temporal selectivities of hippocampal CA3 contributes to sequence disambiguation, which is one of essential functions of the hippocampus. We demonstrate the validity of the suggestion by using sequences assumed from a modified T-maze in which rats perform a task. It should be noted here that CA3c, which is one of the CA3 subregions, generates context-like information that contributes to sequence disambiguation. Finally, we discuss the significance of the context-like information generated in CA3c from a structural and functional viewpoint and suggest that the feedforward and feedback of the context-like information play an essential role in the memory formation of the hippocampus by affecting spatial and temporal information processing in hippocampal dentate gyrus and CA1, respectively.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Eichenbaum, H.: Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 44, 109–120 (2004)
Levy, W.B.: A sequence predicting CA3 is a flexible associator that learns and uses context to solve hippocampal-like tasks. Hippocampus 6, 579–590 (1996)
Samura, T., Hattori, M., Ishizaki, S.: Autoassociative and heteroassociative hippocampal CA3 model based on physiological findings. Abstracts of BrainIT2006 62 (2006)
Samura, T., Hattori, M., Ishizaki, S.: Sequence disambiguation by functionally divided hippocampal CA3 model. In: King, I., Wang, J., Chan, L.-W., Wang, D. (eds.) ICONIP 2006. LNCS, vol. 4232, pp. 117–126. Springer, Heidelberg (2006)
Samura, T., Hattori, M., Ishizaki, S.: Spatial and temporal selectivity of hippocampal CA3 and its contribution to sequence disambiguation. In: de Sá, J.M., Alexandre, L.A., Duch, W., Mandic, D.P. (eds.) ICANN 2007. LNCS, vol. 4669, pp. 49–58. Springer, Heidelberg (2007)
Wood, E.R., Dudchenko, P.A., Robitsek, R.J., Eichenbaum, H.: Hippocampal neurons encode information about different types of memory episodes occurring in the same location. Neuron 27, 623–633 (2000)
Ishizuka, N., Weber, J., Amaral, D.G.: Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J. Comp. Neurol. 295, 580–623 (1990)
Tsukada, M., Aihara, T., Kobayashi, Y., Shimazaki, H.: Spatial analysis of spike-timing-dependent ltp and ltd in the ca1 area of hippocampal slices using optical imaging. Hippocampus 15(1), 104–109 (2005)
Xu, N., Ye, C., Poot, M., Zhang, X.: Coincidence detection of synaptic inputs is facilitated at the distal dendrites after long-term potentiation induction. J. Neurosci. 26(11), 3002–3009 (2006)
Izhikevich, E.M.: Dynamical Systems in Neuroscience: The Geometry of Excitability and Bursting. MIT Press, Cambridge (2007)
Treves, A., Rolls, E.T.: Computational Constraints Suggest the Need for Two Distinct Input Systems to the Hippocampal CA3 Network. Hippocampus 2, 189–200 (1992)
Ishizuka, N., Maxwell, W., Amaral, D.G.: A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus. J. Comp. Neurol. 362, 17–45 (1995)
Levy, W.B., Wu, X., Baxter, R.A.: Unification of hippocampal function via computational/encoding considerations. IJNS 6, 71–80 (1995)
Scharfman, H.E.: The CA3 ”backprojection” to the dentate gyrus. Prog. Brain Res. 163, 627–637 (2007)
Kesner, R.P., Lee, I., Gilbert, P.: A behavioral assessment of hippocampal function based on a subregional analysis. Reviews in the Neurosciences 15, 333–351 (2004)
Miyazawa, Y., Suemitsu, A., Morita, M.: Modeling the activitiy of the hippocampal neurons based on the theory of selective desensitization. The Brain and Neural Networks 14(1), 3–12 (2007) (in Japanese)
Yoshida, M., Hayashi, H.: Emergence of sequence sensitivity in a hippocampal CA3-CA1 model. Neural Networks 20, 653–667 (2007)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Samura, T., Hattori, M., Kikuchi, S., Ishizaki, S. (2009). Significance for Hippocampal Memory of Context-Like Information Generated in Hippocampal CA3c. In: Köppen, M., Kasabov, N., Coghill, G. (eds) Advances in Neuro-Information Processing. ICONIP 2008. Lecture Notes in Computer Science, vol 5506. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02490-0_42
Download citation
DOI: https://doi.org/10.1007/978-3-642-02490-0_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-02489-4
Online ISBN: 978-3-642-02490-0
eBook Packages: Computer ScienceComputer Science (R0)