Abstract
To advance the comprehension of complex biological processes occurring in crop plants (e.g. for improvement of growth or yield) it is of high interest to reconstruct and analyse detailed metabolic models. Therefore, we established a pipeline combining software tools for (1) storage of metabolic pathway data and reconstruction of crop plant metabolic models, (2) simulation and analysis of stoichiometric and kinetic models and (3) visualisation of data generated with these models. The applicability of the approach is demonstrated by a case study of cereal seed metabolism.
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Tilman, D., Hill, J., Lehman, C.: Carbon-Negative Biofuels from Low-Input High-Diversity Grassland Biomass. Science 314(5805), 1598–1600 (2006)
Metzger, J., Bornscheuer, U.: Lipids as renewable resources: current state of chemical and biotechnological conversion and diversification. Applied Microbiology and Biotechnology 71(1), 13–22 (2006)
Scheller, J., Guhrs, K.H., Grosse, F., Conrad, U.: Production of spider silk proteins in tobacco and potato. Nature Biotechnology 19(6), 573–577 (2001)
DellaPenna, D.: Nutritional Genomics: Manipulating Plant Micronutrients to Improve Human Health. Science 285(5426), 375–379 (1999)
Jenner, H.: Transgenesis and yield: what are our targets? Trends in Biotechnology 21(5), 190–192 (2003)
Carrari, F., Urbanczyk-Wochniak, E., Willmitzer, L., Fernie, A.: Engineering central metabolism in crop species: learning the system. Metabolic Engineering 5(3), 191–200 (2003)
Kitano, H.: Systems biology: A brief overview. Science 295(5560), 1662–1664 (2002)
Giersch, C.: Mathematical modelling of metabolism. Current Opinion in Plant Biology 3(3), 249–253 (2000)
Morgan, J., Rhodes, D.: Mathematical modeling of plant metabolic pathways. Metabolic Engineering 4(1), 80–89 (2002)
Poolman, M., Assmus, H., Fell, D.: Applications of metabolic modelling to plant metabolism. Journal of Experimental Botany 55(400), 1177–1186 (2004)
Zhang, P., Foerster, H., Tissier, C., Mueller, L., Paley, S., Karp, P., Rhee, S.: MetaCyc and AraCyc. Metabolic Pathway Databases for Plant Research. Plant Physiology 138(1), 27–37 (2005)
Hucka, M., Finney, A., Sauro, H.M., Bolouri, H., Doyle, J.C., Kitano, H., Arkin, A.P., Bornstein, B.J., Bray, D., Cornish-Bowden, A., Cuellar, A.A., Dronov, S., Gilles, E.D., Ginkel, M., Gor, V., Goryanin, I., Hedley, W.J., Hodgman, T.C., Hofmeyr, J.H., Hunter, P.J., Juty, N.S., Kasberger, J.L., Kremling, A., Kummer, U., Novere, N.L., Loew, L.M., Lucio, D., Mendes, P., Minch, E., Mjolsness, E.D., Nakayama, Y., Nelson, M.R., Nielsen, P.F., Sakurada, T., Schaff, J.C., Shapiro, B.E., Shimizu, T.S., Spence, H.D., Stelling, J., Takahashi, K., Tomita, M., Wagner, J., Wang, J.: The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics 19(4), 524–531 (2003)
Luciano, J.: PAX of mind for pathway researchers. Drug Discovery Today 10(13), 937–942 (2005)
Grafahrend-Belau, E., Weise, S., Koschützki, D., Scholz, U., Junker, B., Schreiber, F.: MetaCrop: a detailed database of crop plant metabolism. Nucleic Acids Research 36(Database issue), D954–D958 (2008)
Weise, S., Grosse, I., Klukas, C., Koschützki, D., Scholz, U., Schreiber, F., Junker, B.H.: Meta-All: a system for managing metabolic pathway information. BMC Bioinformatics 7(1), e465.1–9 (2006)
Varma, A., Palsson, B.: Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use. Nature Biotechnology 12(10), 994–998 (1994)
Kauffman, K., Prakash, P., Edwards, J.: Advances in flux balance analysis. Current Opinion in Biotechnology 14(5), 491–496 (2003)
Junker, B., Klukas, C., Schreiber, F.: VANTED: A system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics 7(1), e109.1–13 (2006)
Hoops, S., Sahle, S., Gauges, R., Lee, C., Pahle, J., Simus, N., Singhal, M., Xu, L., Mendes, P., Kummer, U.: COPASI–a COmplex PAthway SImulator. Bioinformatics 22(24), 3067–3074 (2006)
Hull, D., Wolstencroft, K., Stevens, R., Goble, C., Pocock, M., Li, P., Oinn, T.: Taverna: a tool for building and running workflows of services. Nucleic Acids Research 34(Webserver issue), W729–W732 (2006)
McPhillips, T., Bowers, S., Zinn, D., Ludäscher, B.: Scientific workflow design for mere mortals. Future Generation Computer Systems 25(5), 541–551 (2009)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Weise, S. et al. (2009). An Integration and Analysis Pipeline for Systems Biology in Crop Plant Metabolism. In: Paton, N.W., Missier, P., Hedeler, C. (eds) Data Integration in the Life Sciences. DILS 2009. Lecture Notes in Computer Science(), vol 5647. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02879-3_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-02879-3_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-02878-6
Online ISBN: 978-3-642-02879-3
eBook Packages: Computer ScienceComputer Science (R0)