Abstract
In this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed in previous studies, we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by recent works. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.
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de Castro, A., Fronza, C.F., Giachetto, P.F., Alves, D. (2009). Influence of Antigenic Mutations in Time Evolution of the Immune Memory – A Dynamic Modeling. In: Guimarães, K.S., Panchenko, A., Przytycka, T.M. (eds) Advances in Bioinformatics and Computational Biology. BSB 2009. Lecture Notes in Computer Science(), vol 5676. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03223-3_12
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DOI: https://doi.org/10.1007/978-3-642-03223-3_12
Publisher Name: Springer, Berlin, Heidelberg
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