Abstract
In response to genome stresses, cell can trigger its self-defensive mechanism by regulating the vital genes and their complicated signal pathways. To illustrate the cellular response DNA damage under radiotherapy, a plausible feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of double strand breaks (DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as ion radiation (IR) dose feedback-control are presented.
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Qi, JP., Shao, SH., Shen, YZ. (2009). Plausible Model of Feedback-Control for Cellular Response Based on Gene Regulatory Networks under Radiotherapy. In: Huang, DS., Jo, KH., Lee, HH., Kang, HJ., Bevilacqua, V. (eds) Emerging Intelligent Computing Technology and Applications. ICIC 2009. Lecture Notes in Computer Science, vol 5754. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04070-2_112
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DOI: https://doi.org/10.1007/978-3-642-04070-2_112
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