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Dynamic Identification and Visualization of Gene Regulatory Networks from Time-Series Gene Expression Profiles

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Emerging Intelligent Computing Technology and Applications (ICIC 2009)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5754))

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Abstract

Recent improvements in high-throughput proteomics technology have produced a large amount of time-series gene expression data. The data provide a good resource to uncover causal gene-gene or gene-phenotype relationships and to characterize the dynamic properties of the underlying molecular networks for various biological processes. Several methods have been developed for identifying the molecular mechanisms of regulation of genes from the data, but many of the methods consider static gene expression profiles only. This paper presents a new method for identifying gene regulations from the time-series gene expression data and for visualizing the gene regulations as dynamic gene regulatory networks. The method has been implemented as a program called DRN Builder (Dynamic Regulatory Network Builder; http://wilab.inha.ac.kr/drnbuilder/) and successfully tested on actual gene expression profiles. DRN Builder will be useful for generating potential gene regulatory networks from a large amount of time-series gene expression data and for analyzing the identified networks.

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Author information

Authors and Affiliations

  1. School of Computer Science and Engineering, Inha University, Incheon, Korea

    Yu Chen & Kyungsook Han

Authors
  1. Yu Chen
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  2. Kyungsook Han
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Editor information

Editors and Affiliations

  1. Institute of Intelligent Machines, Chinese Academy of Sciences, China

    De-Shuang Huang

  2. Graduate School of Electrical Engineering, University of Ulsan, Korea, San 29, Mugeo-Dong, Nam-Ku, 680 - 749, Ulsan, Korea

    Kang-Hyun Jo

  3. School of Electrical Engineering, University of Ulsan, Ulsan, South Korea

    Hong-Hee Lee

  4. School of Electrical Engineering, University of Ulsan, South Korea

    Hee-Jun Kang

  5. e.B.I.S. s.r.l. (electronic Business in Security), Spin-Off of Polytechnic of Bari, Str. Prov. per Casamassima Km., 3-70010, Valenzano, (BA), Italy

    Vitoantonio Bevilacqua

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Chen, Y., Han, K. (2009). Dynamic Identification and Visualization of Gene Regulatory Networks from Time-Series Gene Expression Profiles. In: Huang, DS., Jo, KH., Lee, HH., Kang, HJ., Bevilacqua, V. (eds) Emerging Intelligent Computing Technology and Applications. ICIC 2009. Lecture Notes in Computer Science, vol 5754. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04070-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-04070-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04069-6

  • Online ISBN: 978-3-642-04070-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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